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首页> 外文期刊>Radiology >Focal cortical dysplasia: appearance on MR images.
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Focal cortical dysplasia: appearance on MR images.

机译：局灶性皮质发育不良：在MR图像上出现。

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PURPOSE: To clarify the magnetic resonance (MR) imaging characteristics of focal cortical dysplasia (FCD). MATERIALS AND METHODS: The authors reviewed the MR images of 14 patients with FCD, which was confirmed with histologic examination. RESULTS: MR images exhibited FCD in 13 of the 14 patients. All lesions were localized to part of one hemisphere. T2-weighted images showed blurring of the gray matter-white matter junction and abnormal signal intensity in the white matter in 11 patients. T1-weighted images showed blurring of the gray matter-white matter junction in seven patients, broad gyri in nine, thick cortices in nine, abnormal sulci in 10, and focal enlargement of the overlying subarachnoid space or adjacent ventricle in eight. Surgical specimens exhibited disruption of cortical lamination without abnormal gyration in all patients, cytomegalic neurons in the cortex in three, disorganized bizarre glial cells in the cortex in seven, ectopic neurons or bizarre glial cells in the white matter in nine, and blurring of the gray matter-white matter junction in one. CONCLUSION: Blurring of the gray matter-white matter junction with abnormal signal intensity in the white matter on T2-weighted images is characteristic of FCD. The presence of ectopic neurons and bizarre glial cells, dysmyelination, and a reduction in the number of myelinated fibers might have been responsible for the MR imaging characteristics.
机译：目的：阐明局灶性皮质发育异常（FCD）的磁共振（MR）成像特征。材料与方法：作者回顾了14例FCD患者的MR图像，这些图像经组织学检查证实。结果：14例患者中有13例的MR图像显示FCD。所有病变均位于一个半球的一部分。 T2加权图像显示11例患者中灰质-白质连接处模糊，白质中信号强度异常。 T1加权图像显示7例患者灰质-白质交界处模糊，9例广泛回旋，9例较厚皮质，10例异常沟，8例蛛网膜下腔或相邻心室局部扩大。手术标本显示所有患者的皮质层合均无异常回旋，皮质中有巨细胞神经元3个，皮质中有奇异的胶质细胞7个，异位神经元或白质胶质细胞有9个，灰色模糊物质-白物质交界处合而为一。结论：在T2加权图像上，白质中灰质-白质交界处信号强度异常的模糊是FCD的特征。异位神经元和奇异的神经胶质细胞的存在，髓鞘异常和髓鞘纤维数量的减少可能是造成MR成像特征的原因。

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