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首页> 外文期刊>Cellular immunology >Serum levels of immunoglobulins (IgG, IgA, IgM) in Antarctic summer expeditioners and their relationship with seasickness.
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Serum levels of immunoglobulins (IgG, IgA, IgM) in Antarctic summer expeditioners and their relationship with seasickness.

机译：南极夏季探险者的血清免疫球蛋白（IgG，IgA，IgM）水平及其与晕船的关系。

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摘要

The Antarctic continent is full of environmental extremes like isolation, cold, UV exposure, and blizzards etc. The present study was conducted to analyze the effect of ship borne journey and the impact of Antarctic harsh environment on serum immunoglobulin (IgG, IgM, IgA) levels and their relationship with seasickness in Indian expeditioners. It was observed that one month onboard ship journey induced an increase in serum IgA levels and decrease in IgG levels while after being one month off board at the Indian research station Maitri, decreased levels of IgG and increased levels of IgA were found. IgM levels were not altered in comparison to the base line control. Moreover, serum IgG level showed a positive correlation while IgA level showed a negative correlation with seasickness. The stimulation of human peripheral blood mononuclear cells (PBMCs) with serum of expeditioner at different places showed that IgA at lower dose induces the release of pro-inflammatory IL-1beta, and IL-6 cytokines from PBMCs while higher dose of IgA decreases proinflammatory cytokine production. The release of anti-inflammatory cytokines TGF-beta1 and IL-10 was not significantly altered. Thus, the present study concluded that ship borne journey and Antarctic environment lead to increased serum IgA levels while decreased IgG levels. It also suggests that serum IgA level could be a possible biomarker for environmental stress.
机译：南极大陆充满隔离，寒冷，紫外线暴露和暴风雪等极端环境。本研究旨在分析船载航行的影响以及南极恶劣环境对血清免疫球蛋白（IgG，IgM，IgA）的影响的水平和他们与印度探险者晕船的关系。观察到在船上航行一个月会引起血清IgA水平升高和IgG水平下降，而在印度研究站Maitri登船一个月后，发现IgG水平下降和IgA水平升高。与基线对照相比，IgM水平未改变。此外，血清IgG水平与晕船呈正相关，而IgA水平与晕船呈负相关。远征者血清在不同地方刺激人外周血单个核细胞（PBMC）显示，低剂量的IgA诱导PBMCs释放促炎性IL-1beta和IL-6细胞因子，而高剂量的IgA降低促炎细胞因子生产。抗炎细胞因子TGF-beta1和IL-10的释放没有明显改变。因此，本研究得出结论，船上航行和南极环境导致血清IgA水平升高而IgG水平降低。这也表明血清IgA水平可能是环境压力的可能生物标志物。

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