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首页> 外文期刊>Radiology >Relationship between plaque mass and neointimal hyperplasia after stent placement in Yucatan micropigs.
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Relationship between plaque mass and neointimal hyperplasia after stent placement in Yucatan micropigs.

机译：尤卡坦微猪支架置入后斑块质量与新内膜增生之间的关系。

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摘要

PURPOSE: To determine whether the amount of neointima found after stent placement is related to the preexistent plaque mass in the peripheral arteries in micropigs. MATERIALS AND METHODS: Twenty-six peripheral arteries were studied in 14 Yucatan micropigs in a denudation and diet-induced atherosclerosis model. Quantitative angiographic and intravascular ultrasound (US) analysis were performed before and after stent placement and at follow-up 6 weeks after stent placement. At follow-up, the peripheral arterial tree was fixed by means of pressure perfusion, processed for histologic analysis, and analyzed morphometrically with a computer-based system. RESULTS: Preexistent plaque correlated strongly with intimal hyperplasia measured on US images (r = .81, P < .001) or in histologic sections (r = .53, P = .006). No correlation was found between dilation ratio and intimal hyperplasia or between balloon-to-lesion ratio and intimal hyperplasia. In multivariate models of intimal hyperplasia, preexistent plaque and early gain in lumen diameter depicted at angiography were independent explanatory variables. CONCLUSION: The amount of plaque present before stent placement was a determinant of the amount of intimal hyperplasia present after stent placement.
机译：目的：确定在放置支架后发现的新内膜数量是否与微猪周围动脉中先前存在的斑块质量有关。材料与方法：在剥脱和饮食诱发的动脉粥样硬化模型中，对14头尤卡坦微型猪中的26条外周动脉进行了研究。在支架置入前后，以及支架置入后6周进行了定量血管造影和血管内超声（US）分析。随访时，通过压力灌注固定外周动脉树，进行组织学分析，并使用基于计算机的系统进行形态分析。结果：先前斑块与在US图像（r = .81，P <.001）或组织学切片（r = .53，P = .006）上测量的内膜增生高度相关。扩张率与内膜增生之间或球囊病变比与内膜增生之间没有相关性。在内膜增生的多变量模型中，在血管造影术中描绘的斑块和管腔直径的早期增加是独立的解释变量。结论：支架置入前斑块的数量决定了支架置入后内膜增生的数量。

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