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首页> 外文期刊>Radiology >Non-small cell lung cancer: nodal staging with FDG PET versus CT with correlative lymph node mapping and sampling.
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Non-small cell lung cancer: nodal staging with FDG PET versus CT with correlative lymph node mapping and sampling.

机译:非小细胞肺癌:FDG PET和CT的淋巴结分期及相关淋巴结定位和取样。

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摘要

PURPOSE: To prospectively compare the accuracy of positron emission tomography (PET) with 2-[fluorine-18] fluoro-2-deoxy-D-glucose (FDG) with that of computed tomography (CT) in the nodal staging of non-small cell lung cancer. MATERIALS AND METHODS: PET and contrast material-enhanced CT were performed in 47 patients suspected of having or with newly diagnosed non-small cell lung cancer. Each imaging study was evaluated separately, and nodal stations were localized according to the American Thoracic Society mapping system. Extensive lymph node sampling (599 nodes from 191 nodal stations) of the ipsi- and contralateral tracheobronchial and mediastinal nodal stations was performed at thoracotomy and/or mediastinoscopy. Imaging findings were correlated with histopathologic staging results. RESULTS: The sensitivity of PET and CT was 89% and 57%, respectively, for the staging of N2 or N3 disease in mediastinal nodes; specificity was 99% and 94%, respectively; positive predictive value was 96% and 76%, respectively; negative predictive value was 97% and 87%, respectively; and accuracy was 96% and 85%, respectively. In assigning the correct N stage, PET was correct in 96% and CT in 79% of cases. CONCLUSION: PET with FDG appears to be superior to CT for nodal staging of non-small cell lung cancer.
机译:目的:前瞻性比较非小淋巴结分期中正电子发射断层扫描(PET)与2- [氟-18]氟-2-脱氧-D-葡萄糖(FDG)的准确性与计算机断层摄影(CT)的准确性细胞肺癌。材料与方法:对怀疑患有或患有新诊断的非小细胞肺癌的47例患者进行了PET和造影剂增强CT检查。分别评估每个影像学研究,并根据美国胸科学会制图系统对淋巴结进行定位。在开胸和/或纵隔镜下对同侧和对侧气管支气管和纵隔淋巴结的淋巴结进行广泛采样(来自191个淋巴结的599个淋巴结)。影像学检查结果与组织病理学分期结果相关。结果:PET和CT对纵隔淋巴结N2或N3疾病分期的敏感性分别为89%和57%。特异性分别为99%和94%;阳性预测值分别为96%和76%;阴性预测值分别为97%和87%;准确度分别为96%和85%。在分配正确的N期时,PET正确率为96%,CT正确率为79%。结论:PET和FDG在非小细胞肺癌的淋巴结分期中似乎优于CT。

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