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首页> 外文期刊>Radiology >Impaired cerebrovascular autoregulation after hypoxic-ischemic injury in extremely low-birth-weight neonates: detection with power and pulsed wave Doppler US.
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Impaired cerebrovascular autoregulation after hypoxic-ischemic injury in extremely low-birth-weight neonates: detection with power and pulsed wave Doppler US.

机译：出生体重极低的新生儿缺氧缺血性损伤后脑血管自动调节功能受损：用功率和脉冲多普勒超声检查。

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PURPOSE: To evaluate regional cerebral blood flow with power and pulsed wave Doppler ultrasound (US) in extremely low-birth-weight neonates with periventricular leukomalacia (PVL), germinal matrix hemorrhage (GMH), or both. MATERIALS AND METHODS: The lenticulostriate arteries of 17 preterm neonates (birth weight < or = 1,100 g) were assessed daily with Doppler US during the first 5-6 days of life. The mean arterial pressure and bilateral peak velocity, resistive index, coronal vascular cross-sectional area, and product of the peak velocity and vascular cross-sectional area were measured. RESULTS: Five neonates developed PVL, GMH, or both; results of follow-up examinations in 11 patients were normal. One neonate with severe intrauterine growth retardation and renal tubular acidosis was excluded. Neonates with PVL, GMH, or both showed significantly greater mean values and more variable values of vascular cross-sectional area and product of peak velocity and cross-sectional area than neonates without PVL or GMH (P < .025). Mean resistive index was significantly lower in neonates with PVL, GMH, or both than in neonates without (P < .01). There were no significant differences between mean arterial pressure in neonates with and those without PVL, GMH, or both. CONCLUSION: By enabling the detection of autoregulatory fluctuations in cerebral blood flow associated with hypoxic-ischemic injury, power and pulsed wave Doppler US may enable identification of preterm neonates who are at risk of developing PVL, GMH, or both during the 1st week of life.
机译：目的：评估超低出生体重，室周白细胞减少症（PVL），生发性基质出血（GMH）或两者兼有的新生儿，采用功率和脉冲多普勒超声（US）评估局部脑血流。材料与方法：在出生后的头5至6天内每天用多普勒超声评估17例早产儿（出生体重<或= 1,100 g）的扁豆动脉。测量平均动脉压和双侧峰值速度，阻力指数，冠状血管横截面积，以及峰值速度和血管横截面积的乘积。结果：五名新生儿发展了PVL，GMH或两者。 11例患者的随访检查结果均正常。排除一名严重的宫内发育迟缓和肾小管酸中毒的新生儿。与无PVL或GMH的新生儿相比，具有PVL和/或GMH或两者的新生儿显示出明显更高的平均值和更大的可变血管横截面积值，以及峰值速度和横截面积的乘积（P <.025）。有PVL和/或GMH的新生儿的平均电阻指数显着低于无PVL和GMH的新生儿（P <.01）。有和没有PVL，GMH或两者的新生儿的平均动脉压之间无显着差异。结论：通过检测与缺氧缺血性损伤有关的脑血流的自动调节波动，功率多普勒超声和脉搏波多普勒超声可鉴别出在出生后第一周内有发展为PVL，GMH或两者的风险的早产新生儿。

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