...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Radiology >Acute stroke: usefulness of early CT findings before thrombolytic therapy.
【24h】

Acute stroke: usefulness of early CT findings before thrombolytic therapy.

机译：急性中风：溶栓治疗前早期CT检查的有用性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSE: To determine whether the extent of subtle parenchymal hypoattenuation detected on computed tomographic (CT) scans obtained within 6 hours of ischemic stroke is a factor in predicting patients' response to thrombolytic treatment. MATERIALS AND METHODS: The baseline CT scans of 620 patients, who received either recombinant tissue plasminogen activator (rt-PA) or a placebo, in a double-blind, randomized multicenter trial were prospectively evaluated and assigned to one of three categories according to the extent of parenchymal hypoattenuation: none, 33% or less (small), or more than 33% (large) of the middle cerebral artery territory. The association between the extent of hypoattenuation on the baseline CT scans and the clinical outcome in the placebo-treated and the rt-PA-treated groups after 3 months was analyzed. RESULTS: In 215 patients with a small hypoattenuating area, treatment increased the chance of good outcome. In 336 patients with a normal CT scan and in 52 patients with a large hypoattenuating area, rt-PA had no beneficial effect but increased the risk for fatal brain hemorrhage. CONCLUSION: The response to rt-PA in patients with ischemic stroke can be predicted on the basis of initial CT findings of the extent of parenchymal hypoattenuation in the territory of the middle cerebral artery.
机译：目的：确定在缺血性卒中的6小时内通过计算机断层扫描（CT）扫描检测到的微薄的实质性低衰减的程度是否是预测患者对溶栓治疗反应的因素。材料与方法：前瞻性评估了在双盲，随机，多中心试验中对接受重组组织纤溶酶原激活剂（rt-PA）或安慰剂治疗的620例患者的基线CT扫描，并根据以下方法将其分为三类：实质性低衰减的程度：无，大脑中动脉区域的33％或更少（小）或超过33％（大）。分析了3个月后基线CT扫描的低衰减程度与安慰剂治疗组和rt-PA治疗组的临床结局之间的关系。结果：在215个小衰减区域较小的患者中，治疗增加了获得良好结局的机会。在336例CT扫描正常的患者和52例大衰减区域的患者中，rt-PA无效，但增加了致命性脑出血的风险。结论缺血性脑卒中患者对rt-PA的反应可以根据最初的CT表现来预测，即脑中动脉实质实质性减退程度。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号