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首页> 外文期刊>Cell and Tissue Research >Detailed analysis of leucokinin-expressing neurons and their candidate functions in the Drosophila nervous system.
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Detailed analysis of leucokinin-expressing neurons and their candidate functions in the Drosophila nervous system.

机译：果蝇神经系统中表达白细胞分裂素的神经元及其候选功能的详细分析。

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摘要

The distribution of leucokinin (LK) neurons in the central nervous system (CNS) of Drosophila melanogaster was described by immunolabelling many years ago. However, no detailed underlying information of the input or output connections of their neurites was then available. Here, we provide a more accurate morphological description by employing a novel LK-specific GAL4 line that recapitulates LK expression. In order to analyse the possible afferent and efferent neural candidates of LK neurons, we used this lk-GAL4 line together with other CNS-Gal4 lines, combined with antisera against various neuropeptides or neurotransmitters. We found four kinds of LK neurons in the brain. (1) The lateral horn neurons connect the antennal glomerula to the mushroom bodies. (2) The suboesophageal neurons connect the gustatory receptors to the suboesophageal ganglia and ventral nerve cord. (3) The anterior neurons innervate the corpus cardiacum of the ring gland but LK expression is surprisingly not detectable from the third instar onwards in these neurons. (4) A set of abdominal ganglion neurons connect to the dorsal median tract in larvae and send their axons to a segmental muscle 8. Thus, the methods employed in our study can be used to identify individual neuropeptidergic neurons and thereby characterize functional cues or developmental transformations in their differentiation.
机译：多色果蝇的中枢神经系统（CNS）中白细胞分裂素（LK）神经元的分布已通过免疫标记进行了描述。但是，没有可用的神经突的输入或输出连接的详细基础信息。在这里，我们通过概述LK表达的新型LK特异性GAL4系，提供了更准确的形态学描述。为了分析LK神经元的可能传入和传出神经候选者，我们将该lk-GAL4系与其他CNS-Gal4系一起使用，并结合了针对各种神经肽或神经递质的抗血清。我们在大脑中发现了四种LK神经元。 （1）侧角神经元将触角小球连接到蘑菇体。 （2）食管下神经元将味觉受体连接到食管下神经节和腹侧神经索。 （3）前神经元支配着环形腺的cardiac门肌，但是令人惊讶的是，从这些神经元的第三龄开始，LK表达无法检测到。 （4）一组腹部神经节神经元连接到幼虫的背中正道，并将其轴突发送至节段肌8。因此，我们的研究方法可用于鉴定单个神经肽能神经元，从而表征功能提示或发育差异化的转变。

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