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首页> 外文期刊>Radiology >Decreased acute toxicity by using midline mucosa-sparing blocks during radiation therapy for carcinoma of the oral cavity, oropharynx, and nasopharynx.
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Decreased acute toxicity by using midline mucosa-sparing blocks during radiation therapy for carcinoma of the oral cavity, oropharynx, and nasopharynx.

机译：在口腔癌，口咽癌和鼻咽癌的放射治疗过程中使用中线黏膜保留块降低急性毒性。

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PURPOSE: To determine whether midline mucosa-sparing blocks (MSBs) protecting the aerodigestive tract can statistically significantly reduce acute toxicity during radiation therapy for carcinoma of the head and neck, without compromising tumor control. MATERIALS AND METHODS: Radiation records and simulation films were reviewed in 125 patients with carcinoma of the oral cavity, oropharynx, or nasopharynx. Patients with and without MSBs were compared. Measures of acute toxicity during radiation therapy were weight loss (> or = 5%), hospitalization for nutritional support, and unplanned treatment interruptions (> or = 5 days). Actuarial local-regional tumor control was compared. RESULTS: Patients with MSBs had significantly less weight loss (26 of 50 vs 37 of 47 patients, P = .006), fewer hospitalizations for nutritional support (one of 61 vs seven of 64 patients, P = .04), and a trend toward fewer treatment interruptions (10 of 61 vs 19 of 64 patients, P = .07) than patients without MSBs. The 3-year actuarial tumor control rates in the neck were similar. CONCLUSION: Midline MSBs decrease acute toxicity during radiation therapy for carcinoma of the oral cavity, oropharynx, and nasopharynx without compromising tumor control.
机译：目的：确定在保护头颈癌的放疗过程中，保护中风消化道的中线黏膜保留阻滞剂（MSBs）是否能在统计学上显着降低急性毒性，而又不影响对肿瘤的控制。材料与方法：对125例口腔，口咽或鼻咽癌患者的放射记录和模拟胶片进行了回顾。比较有无MSB的患者。放射治疗期间的急性毒性指标包括体重减轻（>或= 5％），营养支持住院以及计划外的治疗中断（>或= 5天）。比较精算局部肿瘤控制。结果：MSB患者的体重减轻明显减少（50名患者中的26名vs 47名患者中的37名，P = .006），营养支持的住院治疗次数减少（61名患者中的64名患者中的7名患者，P = .04），并且有趋势与没有MSB的患者相比，治疗中断更少（61名患者中的10名vs 64名患者中的19名，P = .07）。颈部的3年精算肿瘤控制率相似。结论：中线MSB可降低放射治疗口腔癌，口咽癌和鼻咽癌的急性毒性，而不会影响肿瘤的控制。

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