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首页> 外文期刊>Cell biochemistry and biophysics >Theoretical description of the ion transport across nanopores with titratable fixed charges: analogies between ion channels and synthetic pores.
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Theoretical description of the ion transport across nanopores with titratable fixed charges: analogies between ion channels and synthetic pores.

机译：具有可滴定固定电荷的跨纳米孔离子迁移的理论描述：离子通道与合成孔之间的类比。

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摘要

Recently developed nanometer-sized synthetic pores display several properties so far believed to be distinctive features of a large variety of biological wide ion channels. Thus conductance in the pS-nS range, pH-dependent ion selectivity, fluctuations of current between open and closed states, flux inhibition caused by protons or divalent cations, current rectification, and the ability to perform selective macromolecule sizing and counting are found in synthetic and biological channels alike. Despite other differences such as pore size and geometry, the similarities open a new field for exploring specific technological applications via the chemical modification of synthetic pores with biological molecules. This article reviews some of the basic concepts and theories relevant to ion transport in nanopores with titratable charges stressing the analogies between synthetic pores and biological ion channels. The ultimate goal is to show that continuum theories may account for the essential features of these systems. A simple electrodiffusion model and its comparison with experimental results are chosen as a case study.
机译：最近开发的纳米级合成孔显示出一些特性，到目前为止，这些特性被认为是多种生物宽离子通道的显着特征。因此，在合成中发现了在pS-nS范围内的电导率，pH依赖的离子选择性，打开和关闭状态之间电流的波动，质子或二价阳离子引起的通量抑制，电流整流以及执行选择性大分子尺寸计算的能力。和生物渠道一样。尽管存在其他差异，例如孔径和几何形状，但相似之处为通过生物分子对合成孔的化学修饰而探索特定技术应用开辟了新领域。本文回顾了与可滴定电荷的纳米孔中离子迁移有关的一些基本概念和理论，这些离子和电荷强调了合成孔和生物离子通道之间的类比。最终目标是证明连续论可以解释这些系统的基本特征。以简单的电扩散模型及其与实验结果的比较作为案例研究。

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