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首页> 外文期刊>Cellular immunology >Identification of hepatitis C virus (HCV) 2a-derived epitope peptides having the capacity to induce cytotoxic T lymphocytes in human leukocyte antigen-A24(+) and HCV2a-infected patients
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Identification of hepatitis C virus (HCV) 2a-derived epitope peptides having the capacity to induce cytotoxic T lymphocytes in human leukocyte antigen-A24(+) and HCV2a-infected patients

机译：鉴定丙型肝炎病毒（HCV）2a衍生的表位肽具有诱导人白细胞抗原-A24（+）和HCV2a感染患者细胞毒性T淋巴细胞的能力

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Since virus-specific cytotoxic T lymphocytes (CTLs) play a critical role in preventing the spread of hepatitis C virus (HCV), vaccine-based HCV-specific CTL induction could be a promising strategy to treat HCV-infected patients. In this study, we tried to identify HCV2a-derived epitopes, which can induce human leukocyte antigen (HLA)-A24-restrieted and peptide-specific CTLs. Peripheral blood mononuclear cells of HCV2a-infected patients or healthy donors were stimulated in vitro with HCV2a-derived peptides, which were prepared based on the HLA-A24 binding motif. As a result, three peptides (HCV2a 576-584, HCV2a 627-635, and HCV2a 1085-1094) efficiently induced peptide-specific CTLs from HLA-A24(+) HCV2a-infected patients as well as healthy donors. The cytotoxicity was exhibited by peptide-specific CD8(+) T cells in an HLA-A24-restricted manner. In addition, the HCV2a 627-635 peptide was frequently recognized by immunoglobulin G of HCV2a-infected patients. These results indicate that the identified three HCV2a peptides might be applicable to peptide-based immunotherapy for HLA-A24(+) HCV2a-infected patients. (c) 2006 Elsevier Inc. All rights reserved.
机译：由于病毒特异性细胞毒性T淋巴细胞（CTL）在预防丙型肝炎病毒（HCV）的传播中起关键作用，因此基于疫苗的HCV特异性CTL诱导可能是治疗HCV感染患者的有前途的策略。在这项研究中，我们试图确定HCV2a衍生的抗原决定簇，该抗原决定簇可以诱导人白细胞抗原（HLA）-A24还原和肽特异性CTL。用HCV2a衍生的肽体外刺激HCV2a感染患者或健康供体的外周血单核细胞，该肽是基于HLA-A24结合基序制备的。结果，三种肽（HCV2a 576-584，HCV2a 627-635和HCV2a 1085-1094）有效地诱导了感染HLA-A24（+）HCV2a的患者以及健康供体的肽特异性CTL。肽特异性CD8（+）T细胞以HLA-A24限制的方式表现出细胞毒性。此外，HCV2a 627-635肽经常被HCV2a感染患者的免疫球蛋白G识别。这些结果表明，确定的三种HCV2a肽可能适用于HLA-A24（+）HCV2a感染患者的基于肽的免疫治疗。 （c）2006 Elsevier Inc.保留所有权利。

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