Cross-talks between c-Kit and PKC isoforms in HMC-1(560) and HMC-1(560,816) cells. Different role of PKC delta in each cellular line

Tobio Araceli; Alfonso Amparo; Botana Luis M.

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Cross-talks between c-Kit and PKC isoforms in HMC-1(560) and HMC-1(560,816) cells. Different role of PKC delta in each cellular line

机译：HMC-1（560）和HMC-1（560,816）细胞中c-Kit和PKC亚型之间的串扰。 PKCδ在每个细胞系中的不同作用

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The c-kit inhibitor STI571 represents one of the most important treatments for patients with mastocytosis. However, intracellular pathways modulated by this compound are not completely defined. Here, STI571 effect on Protein Kinase C (PKC) regulation is determined in HMC-1 mast cell lines. STI571 activates PKC delta isoform resulting in HMC-1(560) apoptosis. The apoptosis observed is PKC delta-dependent, since PKC delta-silencing avoids STI571 effect, c-kit inhibition implies nuclear PKCS translocation characterized by a clear dependence on actin cytoskeleton integrity in HMC-1(560) cell line, but not in HMC-1(560,816). Therefore, PKC delta modulations can lead to a serious decrease in STI571 treatment-effectiveness. (C) 2014 The Authors. Published by Elsevier Inc.

机译：c-kit抑制剂STI571是肥大细胞增多症患者最重要的治疗方法之一。但是，该化合物调节的细胞内途径尚未完全定义。在这里，STI571对蛋白激酶C（PKC）调节的作用是在HMC-1肥大细胞系中确定的。 STI571激活PKCδ亚型，导致HMC-1（560）凋亡。观察到的凋亡是PKCδ依赖性的，因为PKCδ沉默可避免STI571效应，c-kit抑制作用意味着核PKCS易位，其特征是对HMC-1（560）细胞系中肌动蛋白细胞骨架完整性的明显依赖性，而对HMC- 1（560,816）。因此，PKC增量调制会导致STI571治疗效果的严重下降。（C）2014作者。由Elsevier Inc.发布

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《Cellular immunology》 |2015年第2期|共9页
作者
Tobio Araceli; Alfonso Amparo; Botana Luis M.;
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正文语种 eng
中图分类细胞生物学;
关键词
HMC-1; PKC; c-kit; STI571; PMA;

机译：UV-1;PKC和c-kit;STI571;PMA;

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2. Cross-talks between c-Kit and PKC isoforms in HMC-1(560) and HMC-1(560,816) cells. Different role of PKC delta in each cellular line [J] . Tobio Araceli, Alfonso Amparo, Botana Luis M. Cellular immunology . 2015,第2期

机译：HMC-1（560）和HMC-1（560,816）细胞中c-Kit和PKC亚型之间的串扰。 PKCδ在每个细胞系中的不同作用
3. The effect of rottlerin in calcium regulation in HMC-1(560) cells is mediated by a PKC-delta independent effect. [J] . Alonso E, Alfonso A, Lober K, Journal of cellular biochemistry. . 2008,第1期

机译：Rottlerin在HMC-1（560）细胞的钙调节中的作用是由PKC-δ独立作用介导的。
4. PKCdelta alternatively spliced isoforms modulate cellular apoptosis in retinoic acid-induced differentiation of human NT2 cells and mouse embryonic stem cells. [J] . Patel NA, Song SS, Cooper DR Gene expression . 2006,第2期

机译：PKCdelta交替剪接的同工型调节视黄酸诱导的人NT2细胞和小鼠胚胎干细胞分化中的细胞凋亡。
5. Regulation of c-Kit Expression In Human Mast Cells Inhibition of SCF-fnduced c-Kit Downregulation by STI 571 (Gleevec) in LAD 2 and HMC-1 Cells [C] . M. Babina, C. Rex, S. Guhl, Collegium Internationale Allergologicum . 2007

机译：在LAD 2和HMC-1细胞中，在人肥大细胞中抑制SCF-Fnduced C-kit的抑制C-kit的调节抑制STI 571（GLEEVEC）和HMC-1细胞
6. How selenium modifies cross-talk between the PIKK family and insights on the regulation of DNA-PKcs [D] . Rocourt, Caroline 2009

机译：硒如何改变PIKK家族之间的相互影响以及对DNA-PKcs调控的见解
7. Identification of novel target genes of nerve growth factor (NGF) in human mastocytoma cell line (HMC-1 (V560G c-Kit)) by transcriptome analysis [O] . Priyanka Dutta, Alexandra Koch, Bjoern Breyer, 2011

机译：通过转录组分析鉴定人肥大细胞瘤细胞系（HMC-1（V560G c-Kit））中神经生长因子（NGF）的新靶基因
8. Cross-talks between c-Kit and PKC isoforms in HMC-1560 and HMC-1560,816 cells. Different role of PKCδ in each cellular line [O] . Tobío Araceli, Alfonso Amparo, Botana Luis M. 2015

机译：HMC-1560和HMC-1560,816细胞中c-Kit和PKC亚型之间的串扰。 PKCδ在每个细胞系中的不同作用

Cross-talks between c-Kit and PKC isoforms in HMC-1(560) and HMC-1(560,816) cells. Different role of PKC delta in each cellular line

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