Complexed soluble IL-7 receptor alpha and IL-7 increase IL-7-mediated proliferation and viability of CD8(+) T-cells in vitro

Cote Sandra; Matte Julie; Sad Subash; Angel Jonathan B.; Crawley Angela M.

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Complexed soluble IL-7 receptor alpha and IL-7 increase IL-7-mediated proliferation and viability of CD8(+) T-cells in vitro

机译：复杂的可溶性IL-7受体α和IL-7在体外增加IL-7介导的CD8（+）T细胞的增殖和活力

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Many soluble cytokine receptors inhibit cytokine bioactivity, while others prolong ligand activity. The biological role of an endogenous soluble form of IL-7R alpha, or its therapeutic effects on CD8(+) T-cells are unknown. We demonstrate that recombinant IL-7R alpha-Fc, when pre-incubated with IL-7, enhances IL-7-induced CD8(+) T-cell proliferation and viability of human or.murine CD8(+) T-cells. Receptor blocking experiments confirmed IL-7-specific activity. These data demonstrate that exogenous soluble IL-7R alpha significantly enhances CD8(+) T-cell responses to IL-7 in vitro and paves the way for future research to determine its therapeutic potential to restore impaired CD8(+) T-cell function in disease. (C) 2015 Elsevier Inc. All rights reserved.

机译：许多可溶性细胞因子受体抑制细胞因子的生物活性，而另一些则延长配体活性。 IL-7Rα的内源可溶性形式的生物学作用或其对CD8（+）T细胞的治疗作用尚不清楚。我们证明重组IL-7Rα-Fc，当与IL-7预孵育时，可增强IL-7诱导的CD8（+）T细胞增殖和人类或鼠CD8（+）T细胞的生存能力。受体阻断实验证实了IL-7的特异性活性。这些数据表明，外源性可溶性IL-7Rα在体外显着增强了CD8（+）T细胞对IL-7的反应，并为未来研究确定其恢复受损CD8（+）T细胞功能的治疗方法铺平了道路。疾病。（C）2015 Elsevier Inc.保留所有权利。

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《Cellular immunology》 |2015年第2期|共4页
作者
Cote Sandra; Matte Julie; Sad Subash; Angel Jonathan B.; Crawley Angela M.;
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正文语种 eng
中图分类细胞生物学;
关键词
Human; Murine; CD8(+) T-cells; IL-7 receptor; Cell proliferation;

机译：人;鼠;CD8（+）T细胞;IL-7受体;细胞增殖;

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专利

1. Complexed soluble IL-7 receptor alpha and IL-7 increase IL-7-mediated proliferation and viability of CD8(+) T-cells in vitro [J] . Cote Sandra, Matte Julie, Sad Subash, Cellular immunology . 2015,第2期

机译：复杂的可溶性IL-7受体α和IL-7在体外增加IL-7介导的CD8（+）T细胞的增殖和活力
2. Effect of cytokines (IL-2, IL-7, and IL-15) having common γ-chain of receptors on differentiation and maturation of CD4+/CD8+ T-cells in a CD45RA T-lymphocyte population in vitro [J] . K. A. Yurova, O. G. Khaziakhmatova, N. A. Dunets, Cell and Tissue Biology . 2017,第5期

机译：细胞因子（IL-2，IL-7和IL-15）对CD45ra T淋巴细胞中CD4 + / CD8 + T细胞的分化和成熟的常见γ链的影响
3. Constitutive Expression of IL-7 Receptor {alpha} Does Not Support Increased Expansion or Prevent Contraction of Antigen-Specific CD4 or CD8 T Cells following Listeria monocytogenes Infection. [J] . Haring JS, Jing X, Bollenbacher-Reilley J, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2008,第5期

机译：IL-7受体{α}的组成型表达不支持单核细胞增生李斯特菌感染后抗原特异性CD4或CD8 T细胞的增加扩增或阻止其收缩。
4. Engineering and Arming of Soluble T-Cell Receptors for Targeting of Tumor Specific HLA Ligands [C] . Dominik Maurer Protein Engineering Summit. . 2018

机译：肿瘤特异性HLA配体靶向可溶性T细胞受体的工程与武装
5. IL-7 and the adult human thymus: In vitro and in vivo studies of a potential immunotherapeutic. [D] . Scripture-Adams, Deirdre Danielle. 2002

机译：IL-7和成人人胸腺：潜在免疫疗法的体外和体内研究。
6. Aberrant plasma IL-7 and soluble IL-7 receptor levels indicate impaired T-cell response to IL-7 in human tuberculosis [O] . Christian Lundtoft, Anthony Afum-Adjei Awuah, Jens Rimpler, 2017

机译：血浆IL-7和可溶性IL-7受体水平异常表明人结核病中T细胞对IL-7的反应受损
7. Aberrant plasma IL-7 and soluble IL-7 receptor levels indicate impaired T-cell response to IL-7 in human tuberculosis. [O] . Christian Lundtoft, Anthony Afum-Adjei Awuah, Jens Rimpler, 2017

机译：异常血浆IL-7和可溶性IL-7受体水平表明T细胞对人结核病中IL-7的反应受损。

Complexed soluble IL-7 receptor alpha and IL-7 increase IL-7-mediated proliferation and viability of CD8(+) T-cells in vitro

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