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首页> 外文期刊>Cellular immunology >Impaired thymopolesis in interleukin-7 receptor transgenic mice is not corrected by Bcl-2
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Impaired thymopolesis in interleukin-7 receptor transgenic mice is not corrected by Bcl-2

机译：Bcl-2不能纠正白介素7受体转基因小鼠的胸腺功能减退

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摘要

Murine thymocytes down-regulate IL-7 responsiveness following P-selection and reacquire sensitivity after positive selection. To assess the potential consequences of IL-7 signaling during this phase of development, transgenic IL-7 receptor alpha (IL-7R alpha) mice were evaluated for IL-7 responsiveness as gauged by STAT-5 phosphorylation. Transgenic IL-7R alpha expression increased the percentage of thymocytes responsive to IL-7 yet resulted in a decrease in total thymic cellularity. Aberrant thymocyte development in transgenic mice was first manifested by a reduction of DN3 thymocytes that correlated with lower Bcl-2 expression. Surprisingly, transgenic restoration of Bcl-2 expression did not correct thymic hypocellularity induced by IL-7R alpha overexpression. These findings demonstrate that failure to appropriately downregulate IL-7R alpha expression interferes with thymocyte development past the pro-T stage resulting in significantly lower levels of mature thymocytes. (c) 2008 Elsevier Inc. All rights reserved.
机译：小鼠胸腺细胞在P选择后下调IL-7反应性，在阳性选择后重新获得敏感性。为了评估在此发育阶段中IL-7信号传导的潜在后果，评估了转基因IL-7受体α（IL-7R alpha）小鼠的IL-7响应能力（通过STAT-5磷酸化来衡量）。转基因IL-7Rα表达增加了对IL-7响应的胸腺细胞的百分比，但导致总胸腺细胞性降低。转基因小鼠的胸腺细胞异常发育首先表现为与Bcl-2表达降低相关的DN3胸腺细胞减少。出人意料的是，Bcl-2表达的转基因恢复不能纠正由IL-7Rα过表达诱导的胸腺细胞性降低。这些发现表明，未能适当下调IL-7Rα表达会干扰胸腺细胞在pro-T阶段后的发育，导致成熟胸腺细胞的水平明显降低。 （c）2008 Elsevier Inc.保留所有权利。

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