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Chemical inactivation of Pat1: A novel approach to synchronize meiosis

机译：Pat1的化学灭活：一种同步减数分裂的新方法

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摘要

Progress in the characterization of meio-sis requires the development of tools that improve synchrony, thus facilitating biochemical and cytological analysis. In the fission yeast Schizosaccharomyces pombe, meiosis occurs under starvation conditions in diploid cells (azygotic meiosis) or in zygotes formed after conjugation between haploids of opposite mating type (zygotic meiosis). A key step in the induction of fission yeast meiosis is the inactivation of the Pat1 protein kinase. Pat1 phosphorylates and inhibits the master regulator of meiosis Mei2 and the transcription factor Ste11, preventing meiosis in haploid cells and/or in the presence of nutrients. Ste11 levels increase under nitrogen starvation; leading to the transcription of its targets, including roe/2 and the mating type genes. The products of the mating type genes form a heterodimer that activates the expression of the Pat1 inhibitor Mei3.
机译：减数分裂表征的进展要求开发改善同步性的工具，从而促进生化和细胞学分析。在裂殖酵母粟酒裂殖酵母中，减数分裂发生在饥饿条件下的二倍体细胞（合子减数分裂）或相反交配型单倍体之间结合后形成的合子（合子减数分裂）。诱导裂变酵母减数分裂的关键步骤是Pat1蛋白激酶的失活。 Pat1磷酸化并抑制减数分裂Mei2和转录因子Ste11的主调节剂，从而防止单倍体细胞和/或营养物质存在下的减数分裂。在氮饥饿状态下，Ste11水平增加;导致其靶标的转录，包括roe / 2和交配型基因。交配型基因的产物形成异二聚体，该异二聚体激活Pat1抑制剂Mei3的表达。

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