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首页> 外文期刊>Cell cycle >Rapid proliferation of daughter cells lacking particular chromosomes due to multipolar mitosis promotes clonal evolution in colorectal cancer cells
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Rapid proliferation of daughter cells lacking particular chromosomes due to multipolar mitosis promotes clonal evolution in colorectal cancer cells

机译：由于多极有丝分裂，缺少特定染色体的子细胞的快速增殖促进了结直肠癌细胞的克隆进化

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Aneuploidy and chromosome instability (CIN) are hallmarks of the vast majority of solid tumors. However, the origins of aneuploid cells are unknown. The aim of this study is to improve our understanding of how aneuploidy and/or CIN arise and of karyotype evolution in cancer cells. By using fluorescence in situ hybridization (FISH) on cells after long-term live cell imaging,we demonstrated that most (> 90%) of the newly generated aneuploid cells resulted from multipolar divisions. Multipolar division occurred in mononucleated and binucleated parental cells, resulting in variation of chromosome compositions in daughter cells. These karyotypes can have the same chromosome number as their mother clone or lack a copy of certain chromosomes. Interestingly, daughter cells that lost a chromosome were observed to survive and form clones with shorter cell cycle duration. In our model of cancer cell evolution, the rapid proliferation of daughter cells from multipolar mitosis promotes colonal evolution in colorectal cancer cells.
机译：非整倍性和染色体不稳定性（CIN）是绝大多数实体瘤的标志。然而，非整倍体细胞的起源是未知的。这项研究的目的是增进我们对非整倍性和/或CIN的产生方式以及癌细胞核型进化的理解。通过在长期活细胞成像后在细胞上使用荧光原位杂交（FISH），我们证明了大多数（> 90％）新生成的非整倍体细胞是由多极分裂产生的。多核分裂发生在单核和双核亲代细胞中，导致子代细胞染色体组成的变化。这些核型可以具有与其母克隆相同的染色体编号或缺少某些染色体的副本。有趣的是，观察到丢失染色体的子细胞可以存活并形成细胞周期较短的克隆。在我们的癌细胞进化模型中，多极有丝分裂的子代细胞的快速增殖促进了结肠直肠癌细胞的结肠进化。

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