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Gene expression is highly correlated on the chromosome level in urinary bladder cancer

机译：基因表达与膀胱癌的染色体水平高度相关

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Objective: Chromosome correlation maps display correlations between gene expression patterns on the same chromosome. Our goal was to map the genes on chromosome regions and to identify correlations through their location on chromosome regions. Results: The top deregulated molecules among 129 bladder cancer samples were implicated in the PI3K/AKT signaling, cell cycle, Myc-mediated apoptosis signaling and ERK5 signaling pathways. Their most prominent molecular and cellular functions were related to cell cycle, cell death, gene expression, molecular transport and cellular growth and proliferation. Chromosome correlation maps allowed us to detect significantly co-expressed genes along the chromosomes. We identified strong correlations among tumors of Tα-grade 1, as well as for those of Tα-grade 2, in chromosomes 1, 2, 3, 7, 12 and 19. Chromosomal domains of gene co-expression were revealed for the normal tissues, as well. The expression data were further simulated, exhibiting an excellent fit (0.7 R2 0.9). The simulations revealed that along the different samples, genes on same chromosomes are expressed in a similar manner. Materials and Methods: Following microarray analysis we used Ingenuity Pathway Analysis (IPA) to construct gene networks of the co-deregulated genes in bladder cancer. Chromosome mapping, mathematical modeling and data simulations were performed using the WebGestalt and Matlab? softwares. Conclusions: Gene expression is highly correlated on the chromosome level. Chromosome correlation maps of gene expression signatures can provide further information on gene regulatory mechanisms. Gene expression data can be simulated using polynomial functions.
机译：目的：染色体相关图显示同一染色体上基因表达模式之间的相关性。我们的目标是将基因定位在染色体区域上，并通过它们在染色体区域上的位置识别相关性。结果：129个膀胱癌样品中最失调的分子与PI3K / AKT信号传导，细胞周期，Myc介导的细胞凋亡信号传导和ERK5信号传导通路有关。它们最突出的分子和细胞功能与细胞周期，细胞死亡，基因表达，分子转运以及细胞生长和增殖有关。染色体相关图谱使我们能够检测到沿染色体显着共表达的基因。我们在染色体1、2、3、7、12和19的染色体中发现了Tα1级肿瘤和Tα2级肿瘤之间的强相关性。揭示了正常组织中基因共表达的染色体结构域，以及。进一步模拟了表达数据，显示出极好的拟合度（0.7

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