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Transcriptional regulation of blood vessel formation: The role of the CASZ1/Egfl7/RhoA pathway

机译:血管形成的转录调控:CASZ1 / Egfl7 / RhoA途径的作用

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摘要

Formation of a functional vascular system is critical for the delivery of nutrients, the removal of waste, and gas exchange. During vasculogenesis, the de novo formation of blood vessels, mesodermal cells differentiate into endothelial cell precursors that proliferate and migrate to specified locations in the embryo before assembling into cord-like structures to form the primary vascular plexus.1 Redistribution of junctional molecules, establishment of apicobasal polarity, and cell morphology changes all facilitate the opening of vessel lumens.
机译:功能性血管系统的形成对于营养的输送,废物的清除和气体交换至关重要。在血管生成过程中,从头形成血管,中胚层细胞分化为内皮细胞前体,这些内皮细胞前体增殖并迁移到胚胎中的指定位置,然后组装成脐带状结构以形成初级血管丛。1连接分子的重新分布,顶突的极性和细胞形态的变化都促进血管腔的开放。

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