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首页> 外文期刊>Rapid Communications in Mass Spectrometry: RCM >Amino acid and peptide conjugates of protoporphyrin: preparation and analysis by high-performance liquid chromatography, high-performance liquid chromatography/electrospray ionization mass spectrometry and matrix-assisted laser desorption ionization
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Amino acid and peptide conjugates of protoporphyrin: preparation and analysis by high-performance liquid chromatography, high-performance liquid chromatography/electrospray ionization mass spectrometry and matrix-assisted laser desorption ionization

机译：原卟啉的氨基酸和肽结合物：高效液相色谱，高效液相色谱/电喷雾电离质谱和基质辅助激光解吸电离的制备和分析

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摘要

Amino acid and peptide conjugates of protoporphyrin have been prepared by reacting protoporphyringen with cysteine, glutathione and peptides containing a free thiol group under acidic conditions. the conjugates were formed by the addition of the thioamino acids or peptides to the vinyl groups of protoporphyrin during the autoxidation of protoporphyinogen to protoporphyrin and is free-radical-mediated.. The conjugates were separated by high-performance liquid chromatography (HPLC) and characterized by HPLC/electrospray ionization mass spectrometry (HPLC/ESIMS) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS). All the conjugates formed were diconjugates consisting of diastereoisomers. Copyright (C) 2002 John Wiley Sons, Ltd. [References: 7]
机译：通过在酸性条件下使原卟啉与半胱氨酸，谷胱甘肽和含有游离巯基的肽反应，可以制备原卟啉的氨基酸和肽结合物。在原卟啉原自氧化为原卟啉的过程中，通过在原卟啉的乙烯基上添加硫代氨基酸或肽而形成缀合物，并通过自由基介导。通过高效液相色谱（HPLC）分离缀合物，并进行表征HPLC /电喷雾电离质谱（HPLC / ESIMS）和基质辅助激光解吸/电离飞行时间质谱（MALDI-TOFMS）进行分析。形成的所有缀合物都是由非对映异构体组成的双缀合物。版权所有（C）2002 John Wiley Sons，Ltd. [参考：7]

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