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首页> 外文期刊>Cell cycle >Cell cycle control in bacteria and yeast: a case of convergent evolution?
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Cell cycle control in bacteria and yeast: a case of convergent evolution?

机译：细菌和酵母菌的细胞周期控制：趋同进化的情况？

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摘要

Superficially similar traits in phylogenetically unrelated species often result from adaptation to common selection pressures. Examples of convergent evolution are known at the levels of whole organisms, organ systems, gene networks and specific proteins. The phenotypic properties of living things, on the other hand, are determined in large part by complex networks of interacting proteins. Here we present a mathematical model of the network of proteins that controls DNA synthesis and cell division in the alpha-proteobacterium, Caulobacter crescentus. By comparing the protein regulatory circuits for cell reproduction in Caulobacter with that in budding yeast (Saccharomyces cerevisiae), we suggest that convergent evolution may have created similar molecular reaction networks in order to accomplish the same purpose of coordinating DNA synthesis to cell division. Although the genes and proteins involved in cell cycle regulation in prokaryotes and eukaryotes are very different and (apparently) phylogenetically unrelated, they seem to be wired together in similar regulatory networks, which coordinate cell cycle events by identical dynamical principles.
机译：在系统发育上无关的物种中，表面相似的性状通常是由于适应共同的选择压力而导致的。在整个生物体，器官系统，基因网络和特定蛋白质的水平上，收敛进化的例子是已知的。另一方面，生物的表型特性在很大程度上取决于相互作用蛋白的复杂网络。在这里，我们介绍了蛋白质网络的数学模型，该蛋白质网络控制alpha变形杆菌Caulobacter crescentus中的DNA合成和细胞分裂。通过比较Caulobacter与芽孢酵母（Saccharomyces cerevisiae）中细胞繁殖的蛋白质调控电路，我们认为融合进化可能已经建立了相似的分子反应网络，以实现协调DNA合成与细胞分裂的相同目的。尽管原核生物和真核生物中涉及细胞周期调控的基因和蛋白质非常不同，并且（显然）在系统发育上不相关，但它们似乎在相似的调控网络中连接在一起，它们通过相同的动力学原理协调细胞周期事件。

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