Use of the anti-inflammatory cytokine interleukin-11 to reverse HIV-1gp120 repression of a natural killer cell line

FavorsS.E.; CurdL.M.; GreggR.K.

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Use of the anti-inflammatory cytokine interleukin-11 to reverse HIV-1gp120 repression of a natural killer cell line

机译：抗炎细胞因子白介素11逆转HIV-1gp120对自然杀伤细胞系的抑制作用

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Enhancing natural killer (NK) cell activation has been associated with protection from human immunodeficiency virus-1 (HIV-1) infections and slowed onset of immunodeficiency. However, soluble HIV-1 envelope protein, gp120, has been shown to impair NK cell cytokine secretion and cell-mediated cytotoxicity. Here we show that gp120 suppressed IFN-γ production and cytotoxic function of a human NK cell line NK-92MI. We furthermore demonstrated that an anti-inflammatory cytokine interleukin-11 can restore effector functions to repressed NK-92MI cells. These studies support the notion that IL-11 administration may reduce HIV-1-mediated immune activation and exhaustion while achieving elimination of virally-infected cells through restored NK cell function.

机译：增强自然杀伤（NK）细胞活化与保护免受人类免疫缺陷病毒1（HIV-1）感染和减缓免疫缺陷发作有关。但是，已显示可溶性HIV-1包膜蛋白gp120会损害NK细胞的细胞因子分泌和细胞介导的细胞毒性。在这里，我们显示gp120抑制人NK细胞系NK-92MI的IFN-γ产生和细胞毒性功能。我们进一步证明抗炎细胞因子白介素11可以恢复效应器功能，以抑制NK-92MI细胞。这些研究支持以下观点：IL-11给药可以减少HIV-1介导的免疫激活和疲劳，同时通过恢复的NK细胞功能消除病毒感染的细胞。

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《Cellular immunology》 |2012年第2期|共5页
作者
FavorsS.E.; CurdL.M.; GreggR.K.;
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正文语种 eng
中图分类细胞生物学;
关键词
Apoptosis; Bcl-X L; Cytotoxicity; Gp120; HIV-1; IFN-γ; IL-11; NK cells; NK-92MI; STAT-3;

机译：凋亡;Bcl-XL;细胞毒性;Gp120;HIV-1;IFN-γ;IL-11;NK细胞;NK-92MI;STAT-3;

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机译：抗炎细胞因子白介素11逆转HIV-1gp120对自然杀伤细胞系的抑制作用
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Use of the anti-inflammatory cytokine interleukin-11 to reverse HIV-1gp120 repression of a natural killer cell line

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