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首页> 外文期刊>Cellular immunology >An assessment of common marmoset (Callithrix jacchus) gamma 9(+) T cells and their response to phosphoantigen in vitro
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An assessment of common marmoset (Callithrix jacchus) gamma 9(+) T cells and their response to phosphoantigen in vitro

机译：普通mar猴（Callithrix jacchus）γ9（+）T细胞及其对磷抗原的体外反应的评估

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摘要

gamma 9 delta 2 T cells are a primate-specific gamma delta T cell subtype that expand and become activated during infection, responding directly to phosphoantigens which are by-products of essential metabolic pathways in both bacteria and mammals. Analogues of natural phosphoantigens have been developed as potential immunotherapeutics for treatment of tumours and infectious diseases. Several non-human primate models have been used in preclinical studies, however, little is known about marmoset gamma 9 delta 2 T cell responses. We identified gamma 9(+) T cells in various tissues in the marmoset and determined that these cells respond to phosphoantigen in a similar manner to human gamma 9 delta 2 T cells in vitro. Both human gamma 9 delta 2 T cells and marmoset gamma 9(+) T cells were able to reduce growth of the intracellular bacterium Burkholderia pseudomallei in vitro following expansion with phosphoantigen. This suggests that the marmoset is an appropriate model for examining the immunotherapeutic potential of compounds which target gamma 9 delta 2 T cells. Crown Copyright (C) 2013 Published by Elsevier Inc. All rights reserved.
机译：γ9δ2 T细胞是灵长类特异性的γδT细胞亚型，在感染过程中会膨胀并被激活，直接响应作为细菌和哺乳动物必需代谢途径副产物的磷酸抗原。已经开发出天然磷酸抗原的类似物作为治疗肿瘤和传染病的潜在免疫疗法。在临床前研究中已经使用了几种非人类的灵长类动物模型，但是，关于mar猴γ9δ2 T细胞反应的了解却很少。我们在the猴的各种组织中鉴定了gamma 9（+）T细胞，并确定这些细胞以与人gamma 9 delta 2 T细胞相似的方式对磷抗原产生反应。人的γ9δ2 T细胞和mar猴γ9（+）T细胞都能够在体外用磷抗原扩增后减少细胞内细菌拟假伯克霍尔德氏菌的生长。这表明the猴是检查靶定于γ9δ2 T细胞的化合物的免疫治疗潜力的合适模型。 Crown版权所有（C）2013，由Elsevier Inc.保留。保留所有权利。

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