AGR2-mediated lung adenocarcinoma metastasis novel mechanism network through repression with interferon coupling cytoskeleton to steroid metabolism-dependent humoral immune response

HuangJ.; WangL.; JiangM.; ChenQ.; JiangZ.; FengH.

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AGR2-mediated lung adenocarcinoma metastasis novel mechanism network through repression with interferon coupling cytoskeleton to steroid metabolism-dependent humoral immune response

机译：AGR2介导的肺腺癌转移新机制网络通过抑制与干扰素偶联的细胞骨架与类固醇代谢依赖的体液免疫反应

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7 anterior gradient homolog 2 (AGR2)-inhibited different molecular mutual positive correlation network was constructed in lung adenocarcinoma compared with human normal adjacent tissues by 17 overlapping molecules of 358 GRNInfer and 19 Pearson (AGR2 CC. ≤. -0.25). Based on GO, KEGG, GenMAPP, BioCarta and disease databases, we determined AGR2-mediated lung adenocarcinoma metastasis through repression with cytoskeleton of MAST1; steroid metabolism of SOAT2; humoral immune response of POU2AF1; interferon alpha-inducible of IFI6; immunoglobulin of IGKC_3, CTA_246H3.1. Thus we proposed AGR2-mediated lung adenocarcinoma metastasis novel mechanism network through repression with interferon coupling cytoskeleton to steroid metabolism-dependent humoral immune response.

机译：与人正常相邻组织相比，在肺腺癌中，通过17个重叠分子358 GRNInfer和19 Pearson（AGR2 CC。≤.-0.25），构建了7个前梯度同源物2（AGR2）抑制的不同分子相互正相关网络。基于GO，KEGG，GenMAPP，BioCarta和疾病数据库，我们通过抑制MAST1的细胞骨架来确定AGR2介导的肺腺癌转移。 SOAT2的类固醇代谢; POU2AF1的体液免疫反应; IFI6的α干扰素诱导型; IGKC_3，CTA_246H3.1的免疫球蛋白。因此，我们提出了通过抑制干扰素将细胞骨架偶联至类固醇代谢依赖的体液免疫反应来抑制AGR2介导的肺腺癌转移的新机制网络。

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《Cellular immunology》 |2014年第1期|共5页
作者
HuangJ.; WangL.; JiangM.; ChenQ.; JiangZ.; FengH.;
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正文语种 eng
中图分类细胞生物学;
关键词
Anterior gradient homolog 2 (AGR2); Humoral immune response; Lung adenocarcinoma; Mechanism;

机译：前梯度同源物2（AGR2）;体液免疫反应;肺腺癌;机制;

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1. AGR2-mediated lung adenocarcinoma metastasis novel mechanism network through repression with interferon coupling cytoskeleton to steroid metabolism-dependent humoral immune response [J] . HuangJ., WangL., JiangM., Cellular immunology . 2014,第1期

机译：AGR2介导的肺腺癌转移新机制网络通过抑制与干扰素偶联的细胞骨架与类固醇代谢依赖的体液免疫反应
2. Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. [J] . M Pasparakis, L Alexopoulou, V Episkopou, The Journal of Experomental Medicine . 1996,第4期

机译：在TNFα缺陷小鼠中的免疫和炎症反应：TNFα在初级B细胞卵泡，卵泡树突细胞网络和生发中心形成的关键要求，以及体液免疫应答的成熟。
3. Type I Interferons Induce T Regulatory 1 Responses and Restrict Humoral Immunity during Experimental Malaria [J] . Amy C. Graham, Bradly E. Burke, Daniel J.J. Carr, PLoS Pathogens . 2016,第10期

机译：I型干扰素在实验性疟疾中诱导T调节1反应并限制体液免疫。
4. Investigations into TKI-Induced Interferon Programs, Immune Microenvironment Interactions and Therapeutic Response in Oncogene Driven Lung Cancer [D] . Gurulé, Natalia Julianne. 2021

机译：调查TKI诱导的干扰素方案，免疫微环境相互作用和癌基因驱动肺癌的治疗反应
5. In vivo blockade of gamma interferon affects the influenza virus-induced humoral and the local cellular immune response in lung tissue. [O] . N Baumgarth, A Kelso 1996

机译：体内γ干扰素的阻断会影响流感病毒诱导的体液和肺组织中的局部细胞免疫反应。
6. Autoantibody Profiles Reveal Ubiquilin 1 as a Humoral Immune Response Target in Lung Adenocarcinoma [O] . Guoan Chen, Xiaoju Wang, Jianjun Yu, 2007

机译：Autoantibody型材揭示肺炎蛋白1作为肺腺癌的体液免疫应答靶标
7. The Cellular and Humoral Immune Response to 'Schistosoma mansoni' Infections in Inbred Rats. V. Prerequisite Mechanisms for the Development of Optimal Protective Immunity. [R] . Phillips, S. M., Reid, W. A., Doughty, B., 1977

机译：近交系大鼠'曼氏血吸虫'感染的细胞和体液免疫应答。 V.开发最佳保护性免疫的先决条件机制。

AGR2-mediated lung adenocarcinoma metastasis novel mechanism network through repression with interferon coupling cytoskeleton to steroid metabolism-dependent humoral immune response

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