TLR7, IFN gamma, and T-bet: Their roles in the development of ABCs in female-biased autoimmunity

Rubtsova Kira; Marrack Philippa; Rubtsov Anatoly V.

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TLR7, IFN gamma, and T-bet: Their roles in the development of ABCs in female-biased autoimmunity

机译：TLR7，IFNγ和T-bet：它们在女性偏向自身免疫中在ABC发育中的作用

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The majority of autoimmune diseases have a strong gender bias, affecting mostly females. Gender-specific factors like sex-hormones, the presence or absence of a second X chromosome, and gender-specific gut microbiota may contribute to this bias. In this review we will discuss the role of the X chromosome encoded toll-like receptor 7 (TLR7) and interferon gamma (IFN gamma) in the development of autoimmunity. We will also review recent data indicating how these factors may affect an immune response in a gender-dependent manner. (C) 2014 Elsevier Inc. All rights reserved.

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《Cellular immunology》 |2015年第2期|共4页
作者
Rubtsova Kira; Marrack Philippa; Rubtsov Anatoly V.;
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正文语种 eng
中图分类细胞生物学;
关键词
Gender; Autoimmunity; TLR7; T-bet; IFNgamma; ABCs;

机译：性别;自身免疫;TLR7;T-bet;IFNγ;ABCs;

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1. TLR7, IFN gamma, and T-bet: Their roles in the development of ABCs in female-biased autoimmunity [J] . Rubtsova Kira, Marrack Philippa, Rubtsov Anatoly V. Cellular immunology . 2015,第2期

机译：TLR7，IFNγ和T-bet：它们在女性偏向自身免疫中在ABC发育中的作用
2. Regulation of IFN-{gamma} Production by B Effector 1 Cells: Essential Roles for T-bet and the IFN-{gamma} Receptor. [J] . Harris DP, Goodrich S, Gerth AJ, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2005,第11期

机译：B效应子1细胞对IFN-γ产生的调节：T-bet和IFN-γ受体的基本作用。
3. IFN-gamma-inducing transcription factor, T-bet is upregulated by estrogen in murine splenocytes: role of IL-27 but not IL-12. [J] . Karpuzoglu E, Phillips RA, Gogal-RM Jr, Molecular Immunology . 2007,第7期

机译：IFN-γ诱导转录因子T-bet在鼠脾细胞中被雌激素上调：IL-27的作用而不是IL-12的作用。
4. IFN-gamma Glycosylation Macroheterogeneity, Energetic Cell Status and Medium Composition During CHO Cell Cultures [C] . N. Kochanowski, F. Blanchard, R. Cacan, European Society of Animal Cell Technology . 2010

机译：IFN-Gamma糖基化即可细胞培养物中的高能量细胞状态和中等组成
5. Long Noncoding RNA Signatures Induced by TLR7 and Type I IFN Signaling in Activated Human Plasmacytoid Dendritic Cells [D] . Joslyn, Rochelle Catherine 2018

机译：TLR7和I型IFN信号转导激活的人浆细胞样树突状细胞中诱导的长非编码RNA特征。
6. TLR7 IFNγ and T-bet: their roles in the development of ABCs in female-biased autoimmunity [O] . Kira Rubtsova, Philippa Marrack, Anatoly V. Rubtsov -1

机译：TLR7IFNγ和T-bet：它们在女性偏向自身免疫中在ABC发育中的作用
7. TLR7, IFNγ, and T-bet: Their roles in the development of ABCs in female-biased autoimmunity [O] . Kira Rubtsova, Philippa Marrack, Anatoly V. Rubtsov 2015

机译：TLR7，IFNγ和T-BET：他们在女性偏见的自身免疫发展中的作用

TLR7, IFN gamma, and T-bet: Their roles in the development of ABCs in female-biased autoimmunity

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