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首页> 外文期刊>Cellular immunology >In vitro and in vivo interactions of aluminum on NTPDase and AChE activities in lymphocytes of rats.
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In vitro and in vivo interactions of aluminum on NTPDase and AChE activities in lymphocytes of rats.

机译：铝对大鼠淋巴细胞NTPDase和AChE活性的体内外相互作用。

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Al adjuvants are used in vaccines to increase the immune response. NTPDase and AChE play a pivotal role and act in the regulation of the immune system. The effect of Al exposure in vitro and in vivo on NTPDase and AChE activities in the lymphocytes of rats was determined. In vitro, ATP hydrolysis was decreased by 20.4% and 17.3% and ADP hydrolysis was decreased by 36.5% and 34.8%, in groups D and E, respectively, when compared to the control. AChE activity was increased by 157.3%, 152.5%, 74.7% and 90.8% in groups B, C, D, and E, respectively, when compared to the control. In vivo, ATP hydrolysis was increased by 85% and 86% and ADP hydrolysis was increased by 104.2% and 74%, in Al plus citrate and Al groups, respectively, when compared to the control. AChE activity was increased by 50.7% in Al plus citrate and by 28.6% in Al groups, when compared to the control. Our results show that Al exposure both in vitro and in vivo altered NTPDase and AChE activities in lymphocytes. These results may demonstrate the ability of Al to elicit the immune system, where NTPDase and AChE activities can act as purinergic and cholinergic markers in lymphocytes.
机译：Al佐剂用于疫苗中以增加免疫反应。 NTPDase和AChE在免疫系统的调节中起着关键作用。确定了体内和体外铝暴露对大鼠淋巴细胞中NTPDase和AChE活性的影响。在体外，与对照组相比，D组和E组的ATP水解分别降低了20.4％和17.3％，ADP水解分别降低了36.5％和34.8％。与对照组相比，B，C，D和E组的AChE活性分别提高了157.3％，152.5％，74.7％和90.8％。在体内，与对照组相比，在铝加上柠檬酸盐和铝组中，ATP水解分别增加了85％和86％，而ADP水解分别增加了104.2％和74％。与对照组相比，铝加柠檬酸盐中的AChE活性增加了50.7％，铝组中的AChE活性增加了28.6％。我们的结果表明，体内和体外的铝暴露都会改变淋巴细胞中NTPDase和AChE的活性。这些结果可以证明A1引发免疫系统的能力，其中NTPDase和AChE活性可以充当淋巴细胞的嘌呤能和胆碱能标记。

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