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首页> 外文期刊>Cell biochemistry and function >Evidence that L-glutamine is better than L-alanine as gluconeogenic substrate in perfused liver of weaned fasted rats submitted to short-term insulin-induced hypoglycaemia.
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Evidence that L-glutamine is better than L-alanine as gluconeogenic substrate in perfused liver of weaned fasted rats submitted to short-term insulin-induced hypoglycaemia.

机译：断奶禁食大鼠短期胰岛素灌流肝脏灌流肝脏中L-谷氨酰胺优于L-谷氨酰胺作为糖异生底物的证据。

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摘要

Gluconeogenesis in livers from overnight fasted weaned rats submitted to short-term insulin-induced hypoglycaemia (IIH) was investigated. For this purpose, a condition of hyperinsulinemia/hypoglycaemia was obtained with an intraperitoneal (ip) injection of regular insulin (1.0 U kg(-1)). Control group (COG group) received ip saline. The studies were performed 30 min after insulin (IIH group) or saline (COG group) injection. The livers from IIH and COG rats were perfused with L-alanine (5 mM), L-lactate (2 mM), L-glutamine (10 mM) or glycerol (2 mM). Hepatic glucose, L-lactate and pyruvate production from L-alanine was not affected by IIH. In agreement with this result, the hepatic ability in producing glucose from L-lactate or glycerol remained unchanged (IIH group vs. COG group). However, livers from IIH rats showed higher glucose production from L-glutamine than livers from COG rats and, in the IIH rats, the production of glucose from L-glutamine was higher than that from L-alanine. The higher glucose production in livers from the IIH group, when compared with the COG group was due to its entrance further on gluconeogenic pathway. Taken together, the results suggest that L-glutamine is better than L-alanine, as gluconeogenic substrate in livers of hypoglycaemic weaned rats.
机译：研究了过夜禁食断奶大鼠短期胰岛素诱导的低血糖症（IIH）在肝脏中的糖异生作用。为此，通过腹膜内（ip）注射常规胰岛素（1.0 U kg（-1））获得了高胰岛素血症/低血糖症。对照组（COG组）接受腹腔注射生理盐水。在注射胰岛素（IIH组）或生理盐水（COG组）后30分钟进行研究。将IIH和COG大鼠的肝脏灌注L-丙氨酸（5 mM），L-乳酸盐（2 mM），L-谷氨酰胺（10 mM）或甘油（2 mM）。 IIH不会影响L-丙氨酸产生的肝葡萄糖，L-乳酸和丙酮酸。与该结果一致，从L-乳酸或甘油产生葡萄糖的肝能力保持不变（IIH组对COG组）。然而，IIH大鼠的肝脏显示出L-谷氨酰胺的葡萄糖生成量高于COG大鼠的肝脏，并且在IIH大鼠中，L-谷氨酰胺生成的葡萄糖生成物高于L-丙氨酸的葡萄糖生成。与COG组相比，IIH组的肝脏中较高的葡萄糖产生是由于其进一步进入糖原异生途径。两者合计，结果表明，L-谷氨酰胺优于L-丙氨酸，因为它是低血糖断奶大鼠肝脏中的糖异生底物。

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