A single bout of dynamic exercise by healthy adults enhances the generation of monocyte-derived-dendritic cells

LaVoy Emily C. P.; Bollard Catherine M.; Hanley Patrick J.; OConnor Daniel P.; Lowder Thomas W.; Bosch Jos A.; Simpson Richard J.

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A single bout of dynamic exercise by healthy adults enhances the generation of monocyte-derived-dendritic cells

机译：健康成年人进行的单次动态运动可增强单核细胞衍生的树突状细胞的生成

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The ex vivo generation of monocyte-derived-dendritic cells (mo-DCs) has facilitated the use of DCs in immunotherapy research. However, low blood monocyte numbers frequently limit the manufacture of sufficient numbers of mo-DCs for subsequent experimental and clinical procedures. Because exercise mobilizes monocytes to the blood, we tested if acute dynamic exercise by healthy adults would augment the generation of mo-DCs without compromising their differentiation or function.-We compared mo-DC generation from before- and after-exercise blood over 8-days of culture. Function was assessed by FITC-dextran uptake and the stimulation of autologous cytomegalovirus (pp65)-specific-T-cells. Supporting the hypothesis, we found a near fourfold increase in number of mo-DCs generated after-exercise. Furthermore, relative FITC-dextran uptake, differentiation rate, and stimulation of pp65-specific-T-cells did not differ between before- and after-exercise mo-DCs. We conclude that exercise enhances the ex vivo generation of mo-DCs without compromising their function, and so may overcome some limitations associated with manufacturing these cells for immunotherapy. (C) 2015 Elsevier Inc. All rights reserved.

机译：单核细胞衍生的树突状细胞（mo-DCs）的离体产生促进了DCs在免疫疗法研究中的使用。然而，低血单核细胞数量经常限制了足够数量的mo-DC的生产，以用于随后的实验和临床程序。由于运动会将单核细胞移动到血液中，因此我们测试了健康成年人的急性动态运动是否会增加mo-DC的生成而不会损害它们的分化或功能。-我们比较了运动前和运动后超过8位血液的mo-DC生成。天的文化。通过FITC-右旋糖酐摄取和自体巨细胞病毒（pp65）特异性T细胞的刺激来评估功能。支持该假设，我们发现运动后生成的mo-DC数量增加了近四倍。此外，运动前后的mo-DC之间的相对FITC-右旋糖酐摄取，分化率和对pp65特异性T细胞的刺激没有差异。我们得出的结论是，锻炼可以增强mo-DC的离体生成而不会损害其功能，因此可以克服与制造用于免疫疗法的这些细胞相关的一些限制。（C）2015 Elsevier Inc.保留所有权利。

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《Cellular immunology》 |2015年第1期|共8页
作者
LaVoy Emily C. P.; Bollard Catherine M.; Hanley Patrick J.; OConnor Daniel P.; Lowder Thomas W.; Bosch Jos A.; Simpson Richard J.;
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正文语种 eng
中图分类细胞生物学;
关键词
Immunotherapy; Dendritic cells; Physical activity; Immunology;

机译：免疫疗法;树突状细胞;体育活动;免疫学;

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1. A single bout of dynamic exercise by healthy adults enhances the generation of monocyte-derived-dendritic cells [J] . LaVoy Emily C. P., Bollard Catherine M., Hanley Patrick J., Cellular immunology . 2015,第1期

机译：健康成年人进行的单次动态运动可增强单核细胞衍生的树突状细胞的生成
2. A single exercise bout enhances the manufacture of viral-specific T-cells from healthy donors: implications for allogeneic adoptive transfer immunotherapy [J] . Guillaume Spielmann, Catherine M. Bollard, Hawley Kunz, Scientific reports. . 2016,第1期

机译：一次运动可以增强健康供体的病毒特异性T细胞的生产：对同种异体过继转移免疫疗法的影响
3. Hemodynamic mechanisms of the attenuated blood pressure response to mental stress after a single bout of maximal dynamic exercise in healthy subjects [J] . A.c.g. Carvalho, A.c.l. Nóbrega, A.r.k. Sales, Brazilian Journal of Medical and Biological Research . 2012,第7期

机译：在健康受试者中进行一次单次最大强度运动后，血压对精神压力的反应减弱的血流动力学机制
4. Changes in properties of red blood cells after single exercise bout before and after cardiac rehabilitation [C] . Gwozdzinski K., Pieniazek A., Czepas J., International Congress on Coronary Artery Disease. . 2013

机译：心脏康复前后单锻炼后红细胞性能变化
5. Sex Differences in Hemodynamics at Rest and During Dynamic Exercise in Healthy Older Adults [D] . Esfandiari, Sam. 2019

机译：健康老年人休息和动态运动中血流动力学的性别差异
6. A single exercise bout enhances the manufacture of viral-specific T-cells from healthy donors: implications for allogeneic adoptive transfer immunotherapy [O] . Guillaume Spielmann, Catherine M. Bollard, Hawley Kunz, -1

机译：一次运动可以增强健康供体的病毒特异性T细胞的生产：对同种异体过继转移免疫疗法的影响
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A single bout of dynamic exercise by healthy adults enhances the generation of monocyte-derived-dendritic cells

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