Dermal gamma delta T cells - What have we learned?

OBrien Rebecca L.; Born Willi K.

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Dermal gamma delta T cells - What have we learned?

机译：皮肤伽玛三角洲T细胞-我们了解了什么？

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Over the last several years, a number of papers have called attention to a distinct population of gamma delta T cells preferentially found in the dermis of the skin of normal mice. These cells appear to play an important role in promoting the development of psoriasis, but also are critical for host resistance to particular pathogens. They are characterized by the expression of a limited subset of gamma delta T cell receptors and a strong propensity to secrete IL-17. Perhaps most importantly, humans appear to carry an equivalent dermal gamma delta T cell population, likewise biased to secrete IL-17 and also implicated as playing a pathogenic role in psoriasis. This review will attempt to summarize and reconcile recent findings concerning the dermal gamma delta T cells. (C) 2015 Elsevier Inc. All rights reserved.

机译：在过去的几年中，许多论文引起了人们对正常小鼠皮肤真皮中优先发现的独特γ-T细胞群体的关注。这些细胞似乎在促进牛皮癣的发展中起重要作用，但对于宿主对特定病原体的抵抗力也至关重要。它们的特征在于表达有限的γ-δT细胞受体子集和强烈分泌IL-17的倾向。也许最重要的是，人类似乎携带着同等的真皮伽马三角洲T细胞种群，同样偏向于分泌IL-17，也暗示其在牛皮癣中起着致病作用。这项审查将试图总结和调和有关皮肤伽玛三角洲T细胞的最新发现。（C）2015 Elsevier Inc.保留所有权利。

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《Cellular immunology》 |2015年第1期|共8页
作者
OBrien Rebecca L.; Born Willi K.;
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正文语种 eng
中图分类细胞生物学;
关键词
Gamma delta T cells; Skin; Dermis; Epidermis; IL-17; CCR6; TCR;

机译：γ-δT细胞;皮肤;真皮;表皮;IL-17;CCR6;TCR;

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1. Dermal gamma delta T cells - What have we learned? [J] . OBrien Rebecca L., Born Willi K. Cellular immunology . 2015,第1期

机译：皮肤伽玛三角洲T细胞-我们了解了什么？
2. Pivotal role of dermal IL-17-producing gammadelta T cells in skin inflammation. [J] . Cai Y, Shen X, Ding C, Immunity . 2011,第4期

机译：产生皮肤的IL-17的Gammadelta T细胞在皮肤炎症中的关键作用。
3. Epidermal and dermal gamma-delta T cells. [J] . Tamaki K, Sugaya M, Tada Y, Chemical immunology . 2001,第0期

机译：表皮和真皮γ-δT细胞。
4. V81~+ gammadelta T cells producing CC chemokines may bridge a gap between neutrophils and macrophages in innate immunity during Escherichia coli infection in mice [C] . Y. Yoshikai, T. Tagawa, K. Shibata, Uehara Memorial Foundation Symposium on the Innate Immune System . 2005

机译：产生CC趋化因子的V81〜+γ肠杆菌T细胞可以在小鼠大肠杆菌感染期间弥合中性粒细胞和巨噬细胞之间的间隙和巨噬细胞
5. Dermal resident versus recruited gammadelta T cell response to cutaneous Vaccinia virus infection. [D] . Davis, Amanda Swale Woodward. 2014

机译：对皮肤痘苗病毒感染的皮肤常驻与募集的γ-T细胞反应。
6. Human fetal liver gamma/delta T cells predominantly use unusual rearrangements of the T cell receptor delta and gamma loci expressed on both CD4+CD8- and CD4-CD8- gamma/delta T cells [O] . 1993

机译：人胎儿肝脏的γ/δT细胞主要使用CD4 + CD8-和CD4-CD8-γ/δT细胞上表达的T细胞受体δ和γ位点的异常重排
7. Human fetal liver gamma/delta T cells predominantly use unusual rearrangements of the T cell receptor delta and gamma loci expressed on both CD4+CD8- and CD4-CD8- gamma/delta T cells [O] . 1993

机译：人胎儿肝脏的γ/δT细胞主要使用CD4 + CD8-和CD4-CD8-γ/δT细胞上表达的T细胞受体δ和γ位点的异常重排

Dermal gamma delta T cells - What have we learned?

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