Research highlights. Makes you think: rescue of radiation-induced cognitive impairments with human embryonic stem cells.

Kerstetter AE; Miller RH

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Research highlights. Makes you think: rescue of radiation-induced cognitive impairments with human embryonic stem cells.

机译：研究亮点。让您想到：用人类胚胎干细胞拯救辐射诱发的认知障碍。

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One undesirable consequence of cranial radiation therapies used in the treatment of a range of neural tumors is the subsequent variable degrees of cognitive dysfunction [1]. The biologic basis for such cognitive deficits is currently unclear. With the realization that specific regions of the adult CNS, such as the dentate gyrus of the hippocampus, retain extensive germinal zones, it has been proposed that radiation causes an inhibition of neu-rogenesis in this region, which results in cognitive impairment. Consistent with this hypothesis, experimental modulation of hippocampal neurogenesis has been correlated with cognitive capacity in a number of animal models.

机译：用于治疗一系列神经肿瘤的颅骨放射疗法的一个不良后果是随之而来的不同程度的认知功能障碍[1]。目前尚不清楚这种认知缺陷的生物学基础。认识到成人中枢神经系统的特定区域，例如海马的齿状回，保留了广阔的生发区，因此提出了辐射会抑制该区域的神经发生，从而导致认知障碍。与该假设一致，在许多动物模型中，海马神经发生的实验性调节与认知能力相关。

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《Regenerative medicine》 |2010年第2期|共2页
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Kerstetter AE; Miller RH;
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中图分类基础医学;
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1. Research highlights. Makes you think: rescue of radiation-induced cognitive impairments with human embryonic stem cells. [J] . Kerstetter AE, Miller RH Regenerative medicine . 2010,第2期

机译：研究亮点。让您想到：用人类胚胎干细胞拯救辐射诱发的认知障碍。
2. Defining the Optimal Window for Cranial Transplantation of Human Induced Pluripotent Stem Cell-Derived Cells to Ameliorate Radiation-Induced Cognitive Impairment [J] . Acharya Munjal M., Martirosian Vahan, Christie Lori-Ann, Stem cells translational medicine. . 2015,第1期

机译：定义人类诱导的多能干细胞衍生细胞颅骨移植以改善辐射诱发的认知障碍的最佳窗口。
3. Defining the Optimal Window for Cranial Transplantation of Human Induced Pluripotent Stem Cell-Derived Cells to Ameliorate Radiation-Induced Cognitive Impairment [J] . Munjal M. Acharya, Vahan Martirosian, Lori-Ann Christie, Stem cells translational medicine. . 2015,第1期

机译：定义人诱导多能干细胞衍生细胞颅移植的最佳窗口，以改善辐射引起的认知障碍
4. A System for Accurate and Sensitive Measurements of Non-Human Glycoprotein Modifications on Human Embryonic Stem Cells. [C] . W. Travis Berggren, Kevin R. Conard, Tenneille E. Ludwig, ASMS Conference on Mass Spectrometry and Allied Topics . 2006

机译：一种用于对人胚胎干细胞的非人糖蛋白修饰的准确和敏感测量的系统。
5. A connection between differentiation and mechanics in human embryonic stem cells. [D] . Rosowski, Kathryn A. 2015

机译：人类胚胎干细胞的分化与力学之间的联系。
6. Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells [O] . Munjal M. Acharya, Lori-Ann Christie, Mary L. Lan, 2009

机译：通过颅内移植人类胚胎干细胞挽救辐射诱发的认知障碍
7. Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells [O] . Acharya, Munjal M., Christie, Lori-Ann, Lan, Mary L., 2009

机译：通过颅内移植人类胚胎干细胞挽救辐射诱发的认知障碍

Research highlights. Makes you think: rescue of radiation-induced cognitive impairments with human embryonic stem cells.

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