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Myb: Getting involved in EMT

机译：Myb：参与EMT

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摘要

A role for transcription factor Myb in breast cancer (BC) has been considered for decades, with substantive data showing an association with estrogen receptor a (ERalpha)-positive BC. Recently, this has been moved into a functional milieu, where Myb-dependent proliferation and impeded differentiation have been established as well as progression in vivo3 and that MYB transcriptional elongation is mediated by ERalpha in an estradiol-dependent manner. High Myb in ERalpha+ BC predicts excellent survival, and some have suggested that MYB is a tumor suppressor gene. Another way to think about this is that this group of BC is very effectively treated. Nevertheless, it is clear that other forms of BC are not so effectively treated yet Myb is still expressed. Whether Myb is important in these is less clear. Central to this lack of clarity is defining the role of Myb in metastasis
机译：转录因子Myb在乳腺癌（BC）中的作用已被研究了数十年，大量数据显示与雌激素受体a（ERalpha）阳性BC相关。最近，这已经转移到功能环境中，其中已经建立了Myb依赖性增殖和阻碍的分化以及体内的进展3，而MYB转录伸长是由ERalpha以雌二醇依赖性的方式介导的。 ERalpha + BC中的Myb较高，预示着良好的存活率，有些人认为MYB是抑癌基因。考虑这一点的另一种方法是，对这组BC的治疗非常有效。然而，很明显，其他形式的BC并未得到有效治疗，但Myb仍被表达。 Myb在这些方面是否重要还不清楚。缺乏明确性的关键是定义Myb在转移中的作用

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