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Feedback regulation of mTORC1 by Grb10 in metabolism and beyond

机译：Grb10在代谢中及以后对mTORC1的反馈调节

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Obesity, which results from imbal-anced energy intake and energy expenditure, is well recognized as a key risk factor for various metabolic and cardiovascular diseases as well as certain types of cancer. Obesity is characterized by excessive expansion of white adipose tissue (WAT) and impaired thermogenic function in brown adipose tissue (BAT). In addition to WAT and BAT, recent studies reveal the presence of a subset of adipocytes in WAT that, in response to environmental or hormonal stimulation, become "brown-like" or "beige" cells. Over the past decade, great progress has been made on our understanding of the anti-obesity benefits of the beige cells and the mechanisms regulating the "beigeing" process at the transcriptional level. However, the upstream signaling pathways regulating the transcriptional machinery involved in the regulation of adipogenesis, thermo-genesis, and adipocyte function remain to be fully characterized.
机译：由不平衡的能量摄入和能量消耗导致的肥胖症是公认的各种代谢和心血管疾病以及某些类型癌症的关键危险因素。肥胖症的特征是白色脂肪组织（WAT）过度膨胀，棕色脂肪组织（BAT）的生热功能受损。除WAT和BAT外，最近的研究表明WAT中存在一部分脂肪细胞，该脂肪细胞响应环境或激素刺激而变成“褐色”或“米黄色”细胞。在过去的十年中，在我们对米色细胞的抗肥胖益处以及在转录水平上调控“米色”过程的机制的理解方面取得了长足的进步。但是，上游信号通路调节参与脂肪形成，热生成和脂肪细胞功能的调节的转录机制仍有待充分表征。

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