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首页> 外文期刊>Cell cycle >Multi-gene fluorescence in situ hybridization to detect cell cycle gene copy number aberrations in young breast cancer patients
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Multi-gene fluorescence in situ hybridization to detect cell cycle gene copy number aberrations in young breast cancer patients

机译：多基因荧光原位杂交技术检测年轻乳腺癌患者细胞周期基因拷贝数异常

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摘要

Breast cancer is a disease of cell cycle, and the dysfunction of cell cycle checkpoints plays a vital role in the occurrence and development of breast cancer. We employed multi-gene fluorescence in situ hybridization (M-FISH) to investigate gene copy number aberrations (CNAs) of 4 genes (Rb1, CHEK2, c-Myc, CCND1) that are involved in the regulation of cell cycle, in order to analyze the impact of gene aberrations on prognosis in the young breast cancer patients. Gene copy number aberrations of these 4 genes were more frequently observed in young breast cancer patients when compared with the older group. Further, these CNAs were more frequently seen in Luminal B type, Her2 overexpression, and triple-negative breast cancer (TNBC) type in young breast cancer patients. The variations of CCND1, Rb1, and CHEK2 were significantly correlated with poor survival in the young breast cancer patient group, while the amplification of c-Myc was not obviously correlated with poor survival in young breast cancer patients. Thus, gene copy number aberrations (CNAs) of cell cycle-regulated genes can serve as an important tool for prognosis in young breast cancer patients.
机译：乳腺癌是一种细胞周期疾病，细胞周期检查点功能异常在乳腺癌的发生和发展中起着至关重要的作用。为了研究细胞周期调控中涉及的4个基因（Rb1，CHEK2，c-Myc，CCND1）的基因拷贝数畸变（CNA），我们采用了多基因荧光原位杂交技术（M-FISH）进行研究。分析基因畸变对年轻乳腺癌患者预后的影响。与老年组相比，年轻乳腺癌患者更经常观察到这4个基因的基因拷贝数异常。此外，这些CNA在年轻乳腺癌患者中更常见于Luminal B型，Her2过表达和三阴性乳腺癌（TNBC）型。在年轻乳腺癌患者组中，CCND1，Rb1和CHEK2的变异与不良生存率显着相关，而c-Myc的扩增与年轻乳腺癌患者的不良生存率无明显相关性。因此，细胞周期调控基因的基因拷贝数异常（CNA）可以作为年轻乳腺癌患者预后的重要工具。

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