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首页> 外文期刊>Renal failure. >Plasma endothelin-1 level, measured glomerular filtration rate and effective renal plasma flow in diabetic nephropathy
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Plasma endothelin-1 level, measured glomerular filtration rate and effective renal plasma flow in diabetic nephropathy

机译：糖尿病肾病患者血浆内皮素-1水平，肾小球滤过率的测定和有效肾血浆流量

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Background: Endothelin-1 (ET-1) is potent vasoconstrictor peptide which is able to contribute to the functional and structural renal changes. The aim of this study was to investigate the relationship between plasma concentration of ET-1 and indices of renal function in patients with diabetic nephropathy. Methods: We measured plasma ET-1 levels in 99 patients with type 2 diabetes, divided into two groups according to the values of their glomerular filtration rate (GFR): group I (GFR >= 60 mL/min/1.73 m(2); n = 50), group II (GFR >= 60 mL/min/1.73 m(2), n = 49), and the control group (n = 30) with clinically healthy subjects who were matched by age and sex. GFR and effective renal plasma flow (ERPF) were measured by the radioisotopic clearance. Other renal function parameters, such as serum concentrations of cystatin C, urea, creatinine, uric acid, 24-h albuminuria and proteinuria were additionally measured. Results: There were significant differences in plasma concentration of ET-1 among groups I, II and the control group (1.45 vs. 2.40 vs. 0.80 pg/mL, p < 0.001). The correlation between ET-1 and mGFR (r = -0.52, p < 0.001), ERPF (r = -0.42, p < 0.001), albuminuria and proteinuria (r = 0.36, p < 0.001; r = 0.48, p < 0.001) and cystatin C (r = 0.42, p < 0.001) was significant. In multiple regression analyses, only plasma concentration of ET-1 (p < 0.001) and duration of hypertension (p < 0.05) were independently and significantly associated with mGFR. Conclusion: A higher plasma concentration of ET-1 is independently associated with a decreased value of GFR in patients with diabetic nephropathy.
机译：背景：内皮素-1（ET-1）是有效的血管收缩肽，能够促进肾功能和结构改变。这项研究的目的是探讨糖尿病肾病患者血浆ET-1浓度与肾功能指标之间的关系。方法：我们测量了99例2型糖尿病患者的血浆ET-1水平，根据其肾小球滤过率（GFR）值分为两组：I组（GFR> = 60 mL / min / 1.73 m（2） ; n = 50），第二组（GFR> = 60 mL / min / 1.73 m（2），n = 49）和对照组（n = 30），其中有年龄和性别相匹配的临床健康受试者。通过放射性同位素清除率测量GFR和有效肾血浆流量（ERPF）。其他肾功能参数，例如血清胱抑素C，尿素，肌酐，尿酸，24小时蛋白尿和蛋白尿的浓度也被测量。结果：I，II组和对照组之间的ET-1血浆浓度存在显着差异（1.45 vs. 2.40 vs. 0.80 pg / mL，p <0.001）。 ET-1与mGFR（r = -0.52，p <0.001），ERPF（r = -0.42，p <0.001），蛋白尿和蛋白尿（r = 0.36，p <0.001; r = 0.48，p <0.001）之间的相关性）和胱抑素C（r = 0.42，p <0.001）显着。在多元回归分析中，只有ET-1的血浆浓度（p <0.001）和高血压持续时间（p <0.05）与mGFR独立且显着相关。结论：糖尿病肾病患者血浆ET-1的升高与GFR值的降低独立相关。

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