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首页> 外文期刊>Cell cycle >Tumor suppression by p53 without accelerated aging: just enough of a good thing?
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Tumor suppression by p53 without accelerated aging: just enough of a good thing?

机译：通过p53抑制肿瘤而不加速衰老：足够好吗？

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摘要

The prevalence of mutations that inactivate the p53 tumor suppressor gene in human cancers reveals the importance of p53 in preventing cancer. Recent progress has generated increased enthusiasm for re-activating p53 in tumors with mutant p53 proteins as well as for increasing p53 function in tumors expressing wild-type p53 that is inhibited in trans. However, excessive p53 activity can be detrimental to the host, potentially limiting the utility of p53 activation as a therapeutic strategy. For example, uncontrolled p53 activity is lethal to the murine embryo, and p53 has been associated with increased aging in people and mice. Here we review the literature linking p53 to aging and discuss reports demonstrating that p53 can suppress tumor formation without accelerating aging. We raise the possibility that activation of p53 remains a promising strategy for cancer chemoprevention and therapy even if, under some circumstances, p53 might accelerate aging.
机译：在人类癌症中普遍存在的使p53抑癌基因失活的突变揭示了p53在预防癌症中的重要性。最近的进展产生了增加的热情，其用突变的p53蛋白重新激活肿瘤中的p53，以及增加了表达被反式抑制的野生型p53的肿瘤中p53功能的热情。但是，过多的p53活性可能对宿主有害，可能会限制p53激活作为治疗策略的实用性。例如，不受控制的p53活性对鼠胚胎具有致死性，并且p53与人和小鼠的衰老增加有关。在这里，我们回顾了将p53与衰老相关的文献，并讨论了证明p53可以抑制肿瘤形成而不加速衰老的报道。我们提出以下可能性：即使在某些情况下p53可能会加速衰老，p53的激活仍然是癌症化学预防和治疗的有前途的策略。

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