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首页> 外文期刊>Cell cycle >ESCRTing cell proliferation off the beaten path: lessons from the drosophila eye.
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ESCRTing cell proliferation off the beaten path: lessons from the drosophila eye.

机译：从人为的途径逃脱细胞增殖：果蝇眼的教训。

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A series of recently published studies have established that defects in endocytic sorting can elicit dramatic tissue overgrowth phenotypes in developing organs of the fruit fly Drosophila melanogaster. Such a link had been suggested by mammalian cell culture experiments almost ten years ago, but in vivo evidence of this link, and the mechanisms through which it might occur, had remained elusive. Drosophila has now proven to be an excellent developmental system in which to both document the effects of endocytic defects on tissue growth and patterning, and to probe the basis of these phenotypes. This work has begun to illuminate some surprising connections between the endocytic trafficking of protein cargoes and the control of cell proliferation and tissue architecture. These connections touch major cell biological processes, including cell division, growth, death, and polarity, and have begun to paint a complex, yet intriguing, picture of how defective endocytic sorting can affect developing tissues.
机译：最近发表的一系列研究表明，内吞分选中的缺陷会在果蝇果蝇的发育器官中引起剧烈的组织过度生长表型。差不多十年前，哺乳动物细胞培养实验已经暗示了这种联系，但是这种联系的体内证据以及可能通过这种途径发生的机制仍然难以捉摸。果蝇现已证明是一个极好的发育系统，在该系统中既可以记录内吞缺陷对组织生长和模式的影响，又可以探测这些表型的基础。这项工作已经开始阐明蛋白质货物的内吞运输与细胞增殖和组织结构控制之间的某些令人惊讶的联系。这些联系涉及主要的细胞生物学过程，包括细胞分裂，生长，死亡和极性，并且已经开始描绘出复杂而有趣的画面，说明有缺陷的内吞分选如何影响发育中的组织。

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