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首页> 外文期刊>Cellular immunology >Tolerogenic dendritic cells generated by RelB silencing using shRNA prevent acute rejection
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Tolerogenic dendritic cells generated by RelB silencing using shRNA prevent acute rejection

机译：使用shRNA的RelB沉默产生的耐受树突状细胞可防止急性排斥

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It is well known that adoptive transfer of donor-derived tolerogenic dendritic cells (DCs) helps to induce immune tolerance. RelB, one of NF-κB subunits, is a critical element involved in DC maturation. In the present study, our results showed tolerogenic DCs could be acquired via silencing RelB using small interfering RNA. Compared with imDCs, the tolerogenic DCs had more potent ability to inhibit mixed lymphocyte reaction (MLR) and down-regulate Th1 cytokines and prompt the production of Th2 cytokines. They both mediated immune tolerance via the increased of T cell apoptosis and generation of regulatory T cells. Administration of donor-derived tolerogenic DCs significantly prevented the allograft rejection and prolonged the survival time in a murine heart transplantation model. Our results demonstrate donor-derived, RelB-shRNA induced tolerogenic DCs can significantly induce immune tolerance . in vitro and . in vivo.
机译：众所周知，过继转移供体来源的致耐受性树突状细胞（DC）有助于诱导免疫耐受。 RelB是NF-κB亚基之一，是参与DC成熟的关键因素。在本研究中，我们的结果表明，可以通过使用小的干扰RNA沉默RelB来获得耐受DC。与imDC相比，致耐受性DC具有更强的抑制混合淋巴细胞反应（MLR）和下调Th1细胞因子并促进Th2细胞因子产生的能力。它们都通过增加T细胞凋亡和生成调节性T细胞来介导免疫耐受。在鼠类心脏移植模型中，给予供体来源的致耐受性DC可以显着防止同种异体移植排斥并延长生存时间。我们的结果表明，供体来源的RelB-shRNA诱导的致耐受性DC可以显着诱导免疫耐受。体外和。体内。

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