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首页> 外文期刊>Cellular immunology >Protective effect of chitin oligosaccharides against lipopolysaccharide-induced inflammatory response in BV-2 microglia
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Protective effect of chitin oligosaccharides against lipopolysaccharide-induced inflammatory response in BV-2 microglia

机译：几丁质寡糖对脂多糖诱导的BV-2小胶质细胞炎症反应的保护作用

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摘要

Chitin oligosaccharides (NA-COS) of two different molecular weight ranges (below 1 and 1-3kDa) were examined for their capabilities against lipopolysaccharide-induced inflammatory responses in BV-2 murine microglia. It was found that NA-COS reduced the level of nitric oxide (NO) and prostaglandin E 2 (PGE 2) production by suppressing the expression of NO synthase (iNOS) and cyclooxygenase (COX)-2 without significant cytotoxicity. Furthermore, the inhibitory effects of NA-COS on generation of interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α were determined. Notably, NA-COS exerted anti-inflammatory activities via blocking degradation of inhibitor of kappaB-alpha (IκB-α), translocation of nuclear factor (NF)-κB, and phosphorylation of mitogen-activated protein kinases (MAPKs) in a dose-dependent manner. These findings provide mechanistic insights into the anti-inflammatory and neuroprotective actions of NA-COS in BV-2 microglia.
机译：检查了两种不同分子量范围（低于1和1-3kDa）的几丁质寡糖（NA-COS）在BV-2鼠小胶质细胞中抵抗脂多糖诱导的炎症反应的能力。发现NA-COS通过抑制NO合酶（iNOS）和环氧合酶（COX）-2的表达而在没有明显的细胞毒性的情况下降低了一氧化氮（NO）和前列腺素E 2（PGE 2）的产生。此外，确定了NA-COS对白介素（IL）-1β，IL-6和肿瘤坏死因子（TNF）-α生成的抑制作用。值得注意的是，NA-COS通过阻断kappaB-α（IκB-α）抑制剂的降解，核因子（NF）-κB的易位以及有丝分裂原激活的蛋白激酶（MAPK）的磷酸化来发挥抗炎活性。依赖方式。这些发现为NA-COS在BV-2小胶质细胞中的抗炎和神经保护作用提供了机械方面的见解。

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