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Oral tolerance correlates with high levels of lymphocyte activity

机译：口服耐受性与高水平的淋巴细胞活性相关

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Oral tolerance is defined as an inhibition of specific immune responsiveness to a previously ingested antigen. Paradoxically, we found an increased lymphocyte activity in tolerant mice alongside the specific inhibition. Orally-tolerant mice presented higher number of immunoglobulin secreting cells (ISC) in spleen and bone marrow; showed a greater variety of Ig classes being produced: IgM and IgA in the spleen and IgG and IgM in the bone marrow. ISC from immunized mice produced mainly IgG. Despite having the same number of regulatory and activated T cells in the spleen after immunization, these cells appeared earlier in tolerant mice, right after the primary immunization. Also, tolerant mice showed a prompt expression of regulatory cytokines (TGF-beta and IL-10) and a transient expression of effector cytokines (IL-2 and IFN-gamma). Thus, in addition to an inhibited specific responsiveness, orally-tolerant mice displayed an early and widespread mobilization of activated and regulatory lymphocytes. (C) 2013 Elsevier Inc. All rights reserved.
机译：口服耐受性定义为对先前摄入的抗原的特异性免疫反应性的抑制。矛盾的是，我们发现耐受性小鼠的淋巴细胞活性增加，同时具有特异性抑制作用。口服耐受小鼠的脾脏和骨髓中免疫球蛋白分泌细胞（ISC）的数量更高;结果显示产生了更多种类的Ig：脾脏中有IgM和IgA，骨髓中有IgG和IgM。来自免疫小鼠的ISC主要产生IgG。尽管免疫后脾脏中的调节性T细胞和活化T细胞数量相同，但这些细胞在初次免疫后立即出现在耐受性小鼠中。此外，耐受性小鼠显示出调节性细胞因子（TGF-β和IL-10）的快速表达和效应细胞因子（IL-2和IFN-γ）的瞬时表达。因此，除了抑制特异性反应之外，口服耐受的小鼠还表现出活化淋巴细胞和调节淋巴细胞的早期和广泛动员。 （C）2013 Elsevier Inc.保留所有权利。

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