Amino acid at position 176 was essential for porcine reproductive and respiratory syndrome virus (PRRSV) non-structural protein 1 alpha (nsp1 alpha) as an inhibitor to the induction of IFN-beta

Shi Xibao; Chen Jing; Xing Guangxu; Zhang Xiaozhuan; Hu Xiaofei; Zhi Yubao; Guo Junqing; Wang Li; Qiao Songlin; Lu Qingxia; Zhang Gaiping

首页> 外文期刊>Cellular immunology >Amino acid at position 176 was essential for porcine reproductive and respiratory syndrome virus (PRRSV) non-structural protein 1 alpha (nsp1 alpha) as an inhibitor to the induction of IFN-beta

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Amino acid at position 176 was essential for porcine reproductive and respiratory syndrome virus (PRRSV) non-structural protein 1 alpha (nsp1 alpha) as an inhibitor to the induction of IFN-beta

机译：176位氨基酸对于猪繁殖与呼吸综合征病毒（PRRSV）非结构蛋白1 alpha（nsp1 alpha）是必需的，可作为诱导IFN-β的抑制剂

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Previous studies have shown that porcine reproductive and respiratory syndrome virus (PRRSV) non-structural protein 1 alpha (nsp1 alpha) was the interferon (IFN) antagonist. However, the mechanism was unclear. In the present study, deletion of the carboxyl-terminal extension (CTE) (167-180 amino acid (aa)) made nsp1 alpha lose its inhibitory ability to the induction of IFN-beta. And a series of C-terminal truncated mutants for nsp1 alpha showed that 1-176 aa of nsp1 alpha was able to inhibit the induction of IFN-beta and deleting or mutating the amino acid F176 made nsp1 alpha not inhibit the induction of IFN-beta. In conclusion, the CTE and the amino acid F176 were critical for nsp1 alpha as the IFN antagonist and the region representing 167-176 was the minimal subunit of the CTE for nsp1 alpha to retain its suppressive activity to the induction of IFN-beta. (C) 2012 Published by Elsevier Inc.

机译：先前的研究表明，猪生殖和呼吸综合症病毒（PRRSV）非结构蛋白1α（nsp1 alpha）是干扰素（IFN）拮抗剂。但是，机制尚不清楚。在本研究中，羧基末端延伸（CTE）（167-180个氨基酸（aa））的缺失使nsp1α失去了其对IFN-β诱导的抑制能力。并且一系列针对nsp1 alpha的C末端截短突变体表明，nsp1 alpha的1-176aa能够抑制IFN-beta的诱导，缺失或突变使nsp1 alpha的氨基酸F176不能抑制IFN-beta的诱导。总之，CTE和氨基酸F176对于nsp1α作为IFN拮抗剂至关重要，而代表167-176的区域是nsp1 alpha的CTE的最小亚基，以保持其对IFN-β诱导的抑制活性。（C）2012由Elsevier Inc.出版

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《Cellular immunology》 |2012年第2期|共7页
作者
Shi Xibao; Chen Jing; Xing Guangxu; Zhang Xiaozhuan; Hu Xiaofei; Zhi Yubao; Guo Junqing; Wang Li; Qiao Songlin; Lu Qingxia; Zhang Gaiping;
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正文语种 eng
中图分类细胞生物学;
关键词
Porcine reproductive and respiratory syndrome virus (PRRSV); Nonstructural protein 1 alpha; Interferon-beta;

机译：猪繁殖与呼吸综合征病毒（PRRSV）;非结构蛋白1α;干扰素-β;

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1. Amino acid at position 176 was essential for porcine reproductive and respiratory syndrome virus (PRRSV) non-structural protein 1 alpha (nsp1 alpha) as an inhibitor to the induction of IFN-beta [J] . Shi Xibao, Chen Jing, Xing Guangxu, Cellular immunology . 2012,第2期

机译：176位氨基酸对于猪繁殖与呼吸综合征病毒（PRRSV）非结构蛋白1 alpha（nsp1 alpha）是必需的，可作为诱导IFN-β的抑制剂
2. The viral non-structural protein 1 alpha (Nsp1 alpha) inhibits p53 apoptosis activity by increasing murine double minute 2 (mdm2) expression in porcine reproductive and respiratory syndrome virus (PRRSV) early-infected cells [J] . Wang Xiaodu, Shao Chunyan, Wang Luyan, Veterinary Microbiology . 2016,第Null期

机译：病毒非结构蛋白1α（Nsp1 alpha）通过增加猪生殖和呼吸综合征病毒（PRRSV）早期感染细胞中的鼠双分2（mdm2）表达来抑制p53细胞凋亡活性
3. Small interfering RNA targeting nonstructural protein1 alpha (nsp1 alpha) of porcine reproductive and respiratory syndrome virus (PRRSV) can reduce the replication of PRRSV in MARC-145 cells [J] . Shi Xibao, Chang Yongzhe, Zhang Xiaozhuan, Research in Veterinary Science . 2015,第Null期

机译：靶向猪繁殖与呼吸综合征病毒（PRRSV）的非结构蛋白1 alpha（nsp1 alpha）的小干扰RNA可以减少PRRSV在MARC-145细胞中的复制
4. INDUCTION OF PORCINE CD4CD25FOXP3+ LYMPHOCYTES BY PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS (PRRSV) [C] . Kaj Chokeshai-usaha, Piya Wongyanin, Supranee Buranapraditkun, Congress of the International Pig Veterinary Society . 2008

机译：猪生殖和呼吸综合征病毒诱导猪CD4CD25FOXP3 +淋巴细胞（PRRSV）
5. Antibody response to non-structural proteins: Implications for diagnostic detection and differentiation of type 1 and type 2 porcine reproductive and respiratory syndrome virus. [D] . Brown, Elizabeth Marie. 2008

机译：抗体对非结构蛋白的应答：对1型和2型猪繁殖与呼吸综合征病毒的诊断检测和分化的意义。
6. A Triple Amino Acid Substitution at Position 88/94/95 in Glycoprotein GP2a of Type 1 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV1) Is Responsible for Adaptation to MARC-145 Cells [O] . Jiexiong Xie, Ivan Trus, Dayoung Oh, 2019

机译：1型猪繁殖与呼吸综合症病毒（PRRSV1）糖蛋白GP2a中88/94/95位的三氨基酸取代负责适应MARC-145细胞
7. Porcine reproductive and respiratory syndrome virus non-structural protein 1 suppresses tumor necrosis factor-alpha promoter activation by inhibiting NF-κB and Sp1 [O] . Subramaniam Sakthivel, Kwon Byungjoon, Beura Lalit K., 2010

机译：猪繁殖与呼吸综合征病毒非结构蛋白1通过抑制NF-κB和Sp1抑制肿瘤坏死因子-α启动子的激活

Amino acid at position 176 was essential for porcine reproductive and respiratory syndrome virus (PRRSV) non-structural protein 1 alpha (nsp1 alpha) as an inhibitor to the induction of IFN-beta

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