Hypoxia and lonizing Radiation: Changes in Adhesive Properties and Cell Adhesion Molecule Expression in MG-63 Three-Dimensional Tumor Spheroids

PAOLA INDOVINA; ANTOINELLA FERRANTE; GABRIELLA RAINALDI; MARIA TERESA SANTINI

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Hypoxia and lonizing Radiation: Changes in Adhesive Properties and Cell Adhesion Molecule Expression in MG-63 Three-Dimensional Tumor Spheroids

机译：低氧和电离辐射：MG-63三维肿瘤球体中的粘附特性和细胞粘附分子表达的变化。

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The effects of chemically induced hypoxia and ionizing radiation on the adhesive properties of MG-63 human osteosarcoma three-dimensional spheroeds were investigates. Hypoxia was induced by addition of CoCl_2 to small, nonhypoxic spheroids and verified by HIF- 1a expression. In addition in inducing adhesive changes were also studies. In particular, two key integirins (i.e., the alpha chain of the fibronectin receptor, a_5, and the alpha chain of the collagen receptor, a_2), an important member of the immunoglobulin superfamily(CD54 or ICAM-1) and the strategic molecule CD44(H-CAM,

机译：研究了化学诱导的缺氧和电离辐射对MG-63人骨肉瘤三维球体黏附特性的影响。缺氧是通过向小的无氧球体中添加CoCl_2诱导的，并通过HIF-1a表达进行了验证。另外，在诱导粘合剂变化方面也进行了研究。特别是，两个关键整联蛋白（即纤连蛋白受体的α链a_5和胶原蛋白受体的α链a_2），免疫球蛋白超家族的重要成员（CD54或ICAM-1）和战略分子CD44 （H-CAM，

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《Cell communication & adhesion》 |2006年第3期|共14页
作者
PAOLA INDOVINA; ANTOINELLA FERRANTE; GABRIELLA RAINALDI; MARIA TERESA SANTINI;
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正文语种 eng
中图分类细胞生物学;
关键词
spheroed; adhesion; hypoxia; ionizing radiation; CAM; fibronectin;

机译：球形;粘附;缺氧;电离辐射;CAM;纤连蛋白;

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1. Hypoxia and lonizing Radiation: Changes in Adhesive Properties and Cell Adhesion Molecule Expression in MG-63 Three-Dimensional Tumor Spheroids [J] . PAOLA INDOVINA, ANTOINELLA FERRANTE, GABRIELLA RAINALDI, Cell communication & adhesion . 2006,第3期

机译：低氧和电离辐射：MG-63三维肿瘤球体中的粘附特性和细胞粘附分子表达的变化。
2. Three-dimensional cell organization leads to a different type of ionizing radiation-induced cell death: MG-63 monolayer cells undergo mitotic catastrophe while spheroids die of apoptosis [J] . Paola Indovina, Gabriella Rainaldi, Maria Teresa Santini International journal of oncology . 2007,第6期

机译：三维细胞组织导致不同类型的电离辐射诱导的细胞死亡：MG-63单层细胞经历有丝分裂灾难，而球体则死于凋亡
3. 1H-NMR evidence for a different response to the same dose (2 Gy) of ionizing radiation of MG-63 human osteosarcoma cells and three-dimensional spheroids. [J] . Santini MT, Romano R, Rainaldi G, Anticancer Research: International Journal of Cancer Research and Treatment . 2006,第1Appa期

机译：1 H-NMR证明对MG-63人骨肉瘤细胞和三维球体的相同剂量（2 Gy）的电离辐射有不同的响应。
4. The strength of adhesion in multicellular tumor spheroids (MCTS) depends on the expression of desmosomal cadherins [C] . Prokhorov A., Svirshchevskaya E. International Congress of Immunology. . 2014

机译：多细胞肿瘤球状体（MCTS）中粘附强度取决于去染色剂钙蛋白的表达
5. Molecular studies on tumor cell-vasculature interactions: Adhesion molecules, endothelial cell retraction, tumor cell spreading, and modulatory role of eicosanoid 12(S)-HETE. [D] . Tang, Dean Guo. 1994

机译：肿瘤细胞与血管系统相互作用的分子研究：粘附分子，内皮细胞收缩，肿瘤细胞扩散和类花生酸12（S）-HETE的调节作用。
6. Hypoxia facilitates tumour cell detachment by reducing expression of surface adhesion molecules and adhesion to extracellular matrices without loss of cell viability. [O] . N. M. Hasan, G. E. Adams, M. C. Joiner, 1998

机译：缺氧通过减少表面粘附分子的表达和对细胞外基质的粘附而促进肿瘤细胞的分离而不会损失细胞的活力。
7. MG-63 human osteosarcoma cells grown in monolayer and as three-dimensional tumor spheroids present a different metabolic profile: a 1H NMR study [O] . Santini Maria Teresa, Rainaldi Gabriella, Romano Rocco, 2004

机译：MG-63人骨肉瘤细胞单层生长，并作为三维肿瘤球体呈现不同的代谢特征：1H NMR研究
8. Eosinophil Cell Lines in a Tri-Cell Multicellular Tumor Spheroid (MTS)/Endothelium Complex: Down Regulation of Adhesion and Integrin Molecules- Implications of Metastasis Inhibition [R] . Furbert-Harris, P. M. 2003

机译：三细胞多细胞肿瘤球体（mTs）/内皮复合物中的嗜酸性粒细胞系：粘附和整合素分子的下调 - 转移抑制的意义

Hypoxia and lonizing Radiation: Changes in Adhesive Properties and Cell Adhesion Molecule Expression in MG-63 Three-Dimensional Tumor Spheroids

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