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Claudins-Key Pieces in the Tight Junction Puzzle

机译:紧密连接拼图中的克劳丁斯关键零件

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摘要

Tight junctions restrict the flow of ions and aqueous molecules between cells by forming a selective barrier to the paracellular pathway. Permeability of the tight junction barrier is determined by a class of transmembrane proteins known as claduins. The relationship between claudins and paracellular permeability is complex and determined not only by the profile of claudin expression but also by the arrangement of claudins and other proteins into tight junction strands. This review summarizes progress in understanding how claudins are assembled into tight junctions and how they interact with other tight junction proteins.
机译:紧密连接通过形成对旁细胞途径的选择性屏障来限制离子和水分子在细胞之间的流动。紧密连接屏障的通透性由一类称为claduins的跨膜蛋白决定。 claudin和细胞旁通透性之间的关系是复杂的,不仅取决于claudin表达的概况,而且取决于claudin和其他蛋白质在紧密连接链中的排列。这篇综述总结了了解claudins如何组装成紧密连接以及它们如何与其他紧密连接蛋白相互作用的进展。

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