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首页> 外文期刊>Cell communication & adhesion >Decreased Plakophilin-1 Expression Promotes Increased Motility in Head and Neck Squamous Cell Carcinoma Cells
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Decreased Plakophilin-1 Expression Promotes Increased Motility in Head and Neck Squamous Cell Carcinoma Cells

机译：Plakophilin-1表达减少促进头颈部鳞状细胞癌细胞的运动性增加。

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摘要

Desmosomes are prominent cell-cell adhesive junctions found in a variety of epithelial tissues, including the oral epithelium. The transmembrane core of the desmosome is composed of the desmosomal cadherins that interact extracellularly to mediate cell-cell adhesion. The cytoplasmic domain of desmosomal cadherins interact with plaque proteins that in turn interact with the keratin intermediate filament cytoskeleton. Plakophilin 1 is a major desmosomal plaque component that functions to recruit intermediate filaments to sites of cell-cell contact via interactions with desmoplakin. Decreased assembly of desmosomes has been reported in several epithelial cancers. We examined plakophilin-1 expression in an esophageal squamous cell carcinoma tissue microarray and found that plakophilin-1 expression inversely correlates with tumor grade. In addition, we sought to investigate the effect of plakophilin-1 expression on desmosome assembly and cell motility in oral squamous cell carcinoma cell lines. Cell lines expressing altered levels of plakophilin-1 were generated and the ability of these cells to recruit desmoplakin to sites of cell-cell contact was examined. Our results show that decreased expression of plakophilin-1 results in decreased desmosome assembly and increased cell motility and invasion. These data lead us to propose that loss of plakophilin-1 expression during head and neck squamous cell carcinoma (HNSCC) progression may contribute to an invasive phenotype.
机译：桥粒是在包括口腔上皮在内的多种上皮组织中发现的突出的细胞-细胞粘附连接。桥粒的跨膜核心由桥粒钙黏着蛋白组成，它们在细胞外相互作用以介导细胞粘附。桥粒钙粘蛋白的胞质结构域与斑块蛋白相互作用，而斑块蛋白又与角蛋白中间丝细胞骨架相互作用。亲脂蛋白1是主要的桥粒斑块组分，其功能是通过与桥粒斑蛋白的相互作用将中间丝募集到细胞-细胞接触的部位。在几种上皮癌中已经报道了桥粒组装的减少。我们在食管鳞状细胞癌组织微阵列中检查了plakophilin-1的表达，发现plakophilin-1的表达与肿瘤等级呈负相关。此外，我们试图调查在口腔鳞状细胞癌细胞系中，嗜珠菌素-1表达对桥粒组装和细胞运动的影响。产生表达改变的亲脂蛋白-1水平的细胞系，并检查了这些细胞将去氨铂素募集到细胞-细胞接触部位的能力。我们的结果表明，Plkaophilin-1的表达降低导致桥粒组装减少，细胞运动和侵袭增加。这些数据使我们建议在头颈部鳞状细胞癌（HNSCC）进展过程中丢失plakophilin-1表达可能会导致侵袭性表型。

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