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首页> 外文期刊>Cellular immunology >Distinct modulation of chemokine expression patterns in human monocyte-derived dendritic cells by prostaglandin E 2
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Distinct modulation of chemokine expression patterns in human monocyte-derived dendritic cells by prostaglandin E 2

机译：前列腺素E 2对人单核细胞来源的树突状细胞趋化因子表达模式的不同调节

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Dendritic cells (DCs) are key in regulating immune responses. DCs reside in tissues facing the environment and sample their surrounding for pathogens. Upon pathogen encounter, DCs mature and migrate into secondary lymphoid organs. Distinct maturation signals dictate the ability of DCs to produce distinct patterns of chemokines that orchestrate immunity. Prostaglandin E 2 (PGE 2) is produced during inflammation and modulates DC functions. We demonstrate that PGE 2 modulates distinct chemokine expression patterns of human monocyte-derived (Mo) DCs upon maturation with various stimuli. PGE 2 dampened early production of the inflammatory chemokines CCL2, CCL4, CCL5 and attenuated the expression of the T cell attractant CXCL10. In contrast, PGE 2 enhanced CXCL8 production early during maturation, whereas CXCL16 levels were continuously elevated, contributing to innate immune cell recruitment. Moreover, PGE 2 induces transcription of the homeostatic chemokines CCL17 and CCL22. Finally, mature MoDCs produced the homing chemokine CCL19 and its expression was down-regulated by PGE 2.
机译：树突状细胞（DC）是调节免疫反应的关键。 DC位于面对环境的组织中，并对其周围的环境进行病原体采样。遇到病原体后，DC会成熟并迁移到次级淋巴器官。不同的成熟信号决定了DC产生协调免疫力的趋化因子模式的能力。前列腺素E 2（PGE 2）在炎症过程中产生并调节DC功能。我们证明，PGE 2会在各种刺激成熟后调节人单核细胞衍生（Mo）DC的独特趋化因子表达模式。 PGE 2抑制炎症趋化因子CCL2，CCL4，CCL5的早期产生，并减弱T细胞引诱剂CXCL10的表达。相比之下，PGE 2在成熟过程的早期提高了CXCL8的产量，而CXCL16的水平却持续升高，从而促进了先天免疫细胞的募集。此外，PGE 2诱导稳态趋化因子CCL17和CCL22的转录。最后，成熟的MoDC产生了归巢趋化因子CCL19，其表达受到PGE 2的下调。

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