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gammadelta T cells develop independently of Aire.

机译：γT细胞独立于Aire发育。

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摘要

Mutations in the transcriptional regulator Aire disrupt thymic alphabeta T cell selection, causing in humans Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). However, it is not known whether Aire is needed for normal gammadelta T cell development. We show that Aire(-/-) mice have a normal frequency of gammadelta T cells, with TCR repertoire comparable to that of wild-type mice, and normal amount of TCR Cdelta mRNA in ileum and skin. gammadelta T cells did not express increased amounts of CD25 or display hyperproliferation, and were not involved in pathological salivary gland infiltrates. Lastly, the frequency of circulating gammadelta T cells was similar in APECED patients and healthy controls. These data indicate that gammadelta T cells develop independently of Aire and are unlikely to have a significant pathogenetic or protective role in APECED. The antigens responsible for gammadelta and alphabeta T cell selection are thus probably largely different.
机译：转录调节因子Aire中的突变破坏了胸腺字母T细胞的选择，从而导致人类自身免疫性多内分泌病-念珠菌病-表皮营养不良（APECED）。然而，尚不知道正常的γ-δT细胞发育是否需要Aire。我们显示，Aire（-/-）小鼠的正常频率的伽玛三角洲T细胞，与野生型小鼠的TCR组成部分相当，回肠和皮肤中TCR Cdelta mRNA的正常含量。 γT细胞不表达增加的CD25量或显示过度增殖，并且不参与病理性唾液腺浸润。最后，在APECED患者和健康对照组中，循环中的Gammadelta T细胞的频率相似。这些数据表明，γT细胞独立于Aire发育，在APECED中不太可能具有重要的致病或保护作用。因此，负责γ和字母T细胞选择的抗原可能有很大的不同。

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