Ligand surface density is important for efficient capture of immunoglobulin and phosphatidylcholine coated particles by human peripheral dendritic cells.

Hellman P; Andersson L; Eriksson H

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Ligand surface density is important for efficient capture of immunoglobulin and phosphatidylcholine coated particles by human peripheral dendritic cells.

机译：配体表面密度对于人外周树突状细胞有效捕获免疫球蛋白和磷脂酰胆碱包被的颗粒很重要。

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A unique property of dealuminated zeolite particles is the exceptional ability to bind both hydrophilic and hydrophobic biomolecules without any covalent linkages. By adsorbing phospholipids onto the particle surface, capture of particles by human peripheral myeloid dendritic cells (mDCs) was observed. Capture of zeolite particles was only seen when a low density of phosphatidylcholine was present on the particles, indicating a specific recognition of the structural features realised by phosphatidylcholine after adsorption on the particle. Adsorbing IgG on the particles revealed capture by mDCs that was dependent upon the density of the IgG molecules. To obtain a smaller particle exposing a high density of IgG molecules, immune complexes (ICs) were formed and both mDCs and pDCs (peripheral plasmacytoid DCs) captured immune complexes, although the mDCs showed a more efficient capture of ICs. As expected, mDCs captured and internalized ICs, whereas pDCs captured ICs but showed no internalization of ICs.

机译：脱铝沸石颗粒的独特性能是在没有任何共价键的情况下结合亲水和疏水生物分子的出色能力。通过将磷脂吸附到颗粒表面，可以观察到人类外周血髓样树突状细胞（mDC）对颗粒的捕获。仅当颗粒上存在低密度的磷脂酰胆碱时才看到沸石颗粒的捕获，这表明对吸附在颗粒上的磷脂酰胆碱实现的结构特征有特定的认识。颗粒上吸附的IgG揭示了mDC的捕获，这取决于IgG分子的密度。为了获得更小的颗粒，暴露出高密度的IgG分子，形成了免疫复合物（ICs），并且mDC和pDC（外周浆细胞样DC）都捕获了免疫复合物，尽管mDC显示出更有效的IC捕获。正如预期的那样，mDC捕获了IC并对其进行了内部化，而pDC捕获了IC，但未实现IC的内部化。

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《Cellular immunology》 |2009年第2期|共8页
作者
Hellman P; Andersson L; Eriksson H;
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正文语种 eng
中图分类细胞生物学;医学免疫学;
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1. Ligand surface density is important for efficient capture of immunoglobulin and phosphatidylcholine coated particles by human peripheral dendritic cells. [J] . Hellman P, Andersson L, Eriksson H Cellular immunology . 2009,第2期

机译：配体表面密度对于人外周树突状细胞有效捕获免疫球蛋白和磷脂酰胆碱包被的颗粒很重要。
2. A cryopreservation method of human peripheral blood mononuclear cells for efficient production of dendritic cells. [J] . Makino M, Baba M Scandinavian journal of immunology. . 1997,第6期

机译：为有效产生树突状细胞而冷冻人外周血单个核细胞的方法。
3. Protease-defective, gp120-containing human immunodeficiency virus type 1 particles induce apoptosis more efficiently than does wild-type virus or recombinant gp120 protein in healthy donor-derived peripheral blood T cells. [J] . M Kameoka, T Kimura, Y H Zheng, Journal of Clinical Microbiology . 1997,第1期

机译：在健康供体来源的外周血T细胞中，含有蛋白酶的，含gp120的人类免疫缺陷病毒1型颗粒比野生型病毒或重组gp120蛋白质更有效地诱导凋亡。
4. MONOCYTES SUPPRESS IMMUNE RESPONSES OF PERIPHERAL BLOOD LYMPHOCYTES: POSSIBLE IMPLICATION OF IMMATURE DENDRITIC CELLS. [C] . M. YAMASHITA, Y. KATAKURA, S. MATSUMOTO, Annual Meeting of the Japanese Association for Animal Cell Technology . 2003

机译：单核细胞抑制外周血淋巴细胞的免疫应答：未成熟树突细胞的可能含义。
5. Surface Plasmon Resonance Studies of the Specific Interactions of Hexamer Peptide Ligands with Human Immunoglobulin G. [D] . Islam, Nafisa. 2013

机译：六聚体肽配体与人免疫球蛋白G特异性相互作用的表面等离子体共振研究。
6. Protease-defective gp120-containing human immunodeficiency virus type 1 particles induce apoptosis more efficiently than does wild-type virus or recombinant gp120 protein in healthy donor-derived peripheral blood T cells. [O] . M Kameoka, T Kimura, Y H Zheng, 1997

机译：在健康供体来源的外周血T细胞中含有蛋白酶的含gp120的人类免疫缺陷病毒1型颗粒比野生型病毒或重组gp120蛋白质更有效地诱导凋亡。
7. Surface immunoglobulin on activated human peripheral blood thymus-derived cells. [O] . Whiteside, T L, Rabin, B S 1976

机译：活化的人外周血胸腺来源的细胞上的表面免疫球蛋白。
8. Surface Immunoglobulin Density on Human Peripheral Blood Mononuclear Cells [R] . Slease, R. B., Wistar, R., Scher, I. 1978

机译：人外周血单个核细胞的表面免疫球蛋白密度

Ligand surface density is important for efficient capture of immunoglobulin and phosphatidylcholine coated particles by human peripheral dendritic cells.

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