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首页> 外文期刊>Cellular immunology >CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity in vivo.
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CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity in vivo.

机译：CD28和ICOS在体内Th2免疫的发展中起互补的非重叠作用。

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Previous work has shown ICOS can function independently of CD28, but whether either molecule can compensate for the other in vivo is not known. Since ICOS is a potent inducer of Th2 cytokines and linked to allergy and elevated serum IgE in humans, we hypothesized that augmenting ICOS costimulation in murine allergic airway disease may overcome CD28 deficiency. While ICOS was expressed on T cells from CD28(-/-) mice, Th2-mediated airway inflammation was not induced in CD28(-/-) mice by increased ICOS costimulation. Further, we determined if augmenting CD28 costimulation could compensate for ICOS deficiency. ICOS(-/-) mice had a defect in airway eosinophilia that was not overcome by augmenting CD28 costimulation. CD28 costimulation also did not fully compensate for ICOS for antibody responses, germinal center formation or the development of follicular B helper T cells. CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity in vivo.
机译：先前的工作表明，ICOS可以独立于CD28发挥功能，但是尚不清楚一个分子能否在体内补偿另一个分子。由于ICOS是Th2细胞因子的有效诱导剂，并且与人类变态反应和血清IgE升高有关，因此我们假设在鼠类过敏性气道疾病中增加ICOS共刺激可能可以克服CD28缺乏症。虽然ICOS在CD28（-/-）小鼠的T细胞上表达，但通过增加ICOS共刺激，在CD28（-/-）小鼠中并未诱导Th2介导的气道炎症。此外，我们确定了增强CD28共刺激是否可以弥补ICOS不足。 ICOS（-/-）小鼠的气道嗜酸性粒细胞增多症不能通过增强CD28共刺激来克服。 CD28共刺激也不能完全补偿ICOS的抗体应答，生发中心的形成或滤泡B辅助T细胞的发育。 CD28和ICOS在体内Th2免疫的发展中起互补的非重叠作用。

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