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首页> 外文期刊>Cellular immunology >Peripheral CD4+CD8+cells are the activated T cells expressed granzyme B (GrB), Foxp3, interleukin 17 (IL-17), at higher levels in Th1/Th2 cytokines.
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Peripheral CD4+CD8+cells are the activated T cells expressed granzyme B (GrB), Foxp3, interleukin 17 (IL-17), at higher levels in Th1/Th2 cytokines.

机译：外周CD4 + CD8 +细胞是活化的T细胞，表达的颗粒酶B（GrB），Foxp3，白介素17（IL-17）在Th1 / Th2细胞因子中含量较高。

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Peripheral CD4+CD8+ T cells have been identified as a T cell subset existing in animals and humans. However, the characterization of CD4+CD8+ T cells, their relationship with T memory (T(M)), T effector (T(E)), Th1/Th2, Treg and Th-17, remain unclear. This study was to characterize the CD4+CD8+ T cells. The results from human subjects showed that activated T cells were CD4+CD8+ T cells, comprised CD4(hi)CD8(lo), CD4(hi)CD8(hi) and CD4(lo)CD8(hi) subsets. They expressed CD62L(hi/lo), granzyme B (GrB), CD25, Foxp3, interleukin 17 (IL-17) and the cytokines of both Th1 and Th2, and had cytolytic function. These findings suggested that CD4+CD8+ T cells had over-lap function while they kept diversity, and that T cells could be divided into two major populations: activated and inactivated. Hence, the hypotheses of Th1/Th2, Treg and Th-17 might reflect the positiveegative feedback regulation of immune system. When compared to GrB+CD62L(lo) T effector (T(E)) cells, GrB+CD62L(hi) T central memory effector (T(CME)) cells had a quicker response to virus without CD62L loss.
机译：外周CD4 + CD8 + T细胞已被鉴定为存在于动物和人类中的T细胞亚群。然而，CD4 + CD8 + T细胞的表征，与T记忆（T（M）），T效应子（T（E）），Th1 / Th2，Treg和Th-17的关系仍不清楚。这项研究旨在表征CD4 + CD8 + T细胞。来自人类受试者的结果表明，活化的T细胞是CD4 + CD8 + T细胞，包括CD4（hi）CD8（lo），CD4（hi）CD8（hi）和CD4（lo）CD8（hi）亚群。他们表达了CD62L（hi / lo），粒酶B（GrB），CD25，Foxp3，白介素17（IL-17）和Th1和Th2的细胞因子，并具有溶细胞功能。这些发现表明，CD4 + CD8 + T细胞在保持多样性的同时具有重叠功能，并且T细胞可分为两个主要种群：活化和失活。因此，Th1 / Th2，Treg和Th-17的假说可能反映了免疫系统的正/负反馈调节。与GrB + CD62L（lo）T效应子（T（E））细胞相比，GrB + CD62L（hi）T中央记忆效应子（T（CME））细胞对病毒的反应更快，而CD62L却没有丢失。

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