The multilayer regulation of the metaphase-to-anaphase transition.

Jin F; Richmond D; Wang Y

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The multilayer regulation of the metaphase-to-anaphase transition.

机译：中期到后期过渡的多层调节。

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The fluctuating activity of the cyclin-dependent kinases (Cdks) is critical for the periodic phosphorylation of a given Cdk substrate. Previous studies have been focus on the positive role of Cdk-dependent protein phosphorylation in cell cycle progression. Recent studies indicate that, in budding yeast, highly active S-phase cyclin-associated Cdk not only promotes DNA synthesis but also inhibits the initiation of chromosome segregation. The FEAR (Cdc14 early anaphase release) pathway alleviates the negative effect of the S-phase cyclin on anaphase by promoting the dephosphorylation of S-phase cyclin-specific substrates, revealing a new layer of regulation in the metaphase-to-anaphase transition.

机译：细胞周期蛋白依赖性激酶（Cdks）的波动活性对于给定Cdk底物的周期性磷酸化至关重要。以前的研究一直集中在Cdk依赖性蛋白磷酸化在细胞周期进程中的积极作用。最近的研究表明，在发芽酵母中，高活性S期细胞周期蛋白相关的Cdk不仅促进DNA合成，而且抑制染色体分离的启动。 FEAR（Cdc14早期后期释放）途径通过促进S期细胞周期蛋白特异性底物的去磷酸化，减轻了S期细胞周期蛋白对后期的负面影响，从而揭示了从中期到后期过渡的新调控层。

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《Cell cycle》 |2009年第5期|共5页
作者
Jin F; Richmond D; Wang Y;
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正文语种 eng
中图分类细胞生物学;
关键词
Anaphase; Cell Cycle Proteins; Chromosome Segregation; Cyclin-Dependent Kinases; 后期; 细胞周期蛋白质类; 染色体分离; 细胞周期蛋白质依赖激酶类; 基因表达调控;

机译：Anaphase;Cell Cycle Proteins;Chromosome Segregation;Cyclin-Dependent Kinases;后期;细胞周期蛋白质类;染色体分离;细胞周期蛋白质依赖激酶类;基因表达调控;

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1. The multilayer regulation of the metaphase-to-anaphase transition. [J] . Jin F, Richmond D, Wang Y Cell cycle . 2009,第5期

机译：中期到后期过渡的多层调节。
2. Degradation of securin in mouse and pig oocytes is dependent on ubiquitin-proteasome pathway and is required for proteolysis of the cohesion subunit, Rec8, at the metaphase-to-anaphase transition. [J] . Huo LJ, Zhong ZS, Liang CG, Frontiers in bioscience: a journal and virtual library . 2006,第1期

机译：小鼠和猪卵母细胞中securin的降解取决于泛素-蛋白酶体途径，并且是在中期到后期过渡过程中凝聚亚基Rec8的蛋白水解所必需的。
3. Regulation of NKG2D signaling during the epithelial-to-mesenchymal transition. [J] . López-Soto A, Zapico LH, Acebes-Huerta A, Oncoimmunology. . 2013,第9期

机译：NKG2D信号传导在上皮到间质转化过程中的调节。
4. Better Late than Never: A Multilayer Network Model Using Metaplasticity for Emotion Regulation Strategies [C] . Nimat Ullah, Jan Treur International Conference on Complex Networks and Their Applications . 2020

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5. Microenvironmental regulation of epithelial-mesenchymal transition. [D] . Chen, Qike Kyle. 2013

机译：上皮-间质转化的微环境调节。
6. BRCA1 phosphorylation by Aurora-A in the regulation of G2to M transition. [O] . Mutsuko Ouchi, Nobuko Fujiuchi, Kaori Sasai, 2015

机译：Aurora-A调节BRCA1磷酸化G2向M过渡。
7. Quantitative analyses of the metaphase-to-anaphase transition reveal differential kinetic regulation for securin and cyclin B1 [O] . Makoto KONISHI, Norihisa SHINDO, Masataka KOMIYA, 2018

机译：中磷酶转变的定量分析显示Securin和Cyclin的差动动力学调节 b1

The multilayer regulation of the metaphase-to-anaphase transition.

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