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首页> 外文期刊>Cell cycle >Metformin extends life span of HER-2eu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo.
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Metformin extends life span of HER-2eu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo.

机译：二甲双胍可延长HER-2 / neu转基因小鼠的寿命，并与褪黑激素联合使用可抑制体内可移植肿瘤的生长。

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Population studies have shown that treatment with the antidiabetic biguanide metformin significantly reduced cancer risk. In our animal studies, metformin delayed the onset of mammary adenocarcinoma (MAC) in transgenic HER-2eu mice but not the onset of spontaneous mammary tumors in female SHR mice. Pineal hormone also inhibits mammary carcinoma development in HER2eu transgenic mice as well as in female SHR mice. Here we demonstrated that a combination of metformin and melatonin significantly inhibits growth of transplanted tumors in mice. Metformin (0.5 mg/ml in drinking water) increased mean life span by 8% and MAC latency by 13.2% (p < 0.05) in HER2eu mice. The treatment with melatonin alone (2 mg/L in drinking water during the night time) or combined treatment with metformin (0.5 mg/ ml in drinking water during the day time) + melatonin (2 mg/L in drinking water during the night time) did not influence mammary carcinogenesis in the mice. The treatment metformin alone inhibited the growth of transplantable HER2 mammary carcinoma in FVB/N male mice by 46% at the 45(th) day after transplantation (p < 0.001). The combined treatment with metformin + melatonin significantly suppressed Ehrlich tumor growth (by 40%, p < 0.001). These results suggest that metformin may be useful in prevention and treatment of breast cancer.
机译：人群研究表明，用抗糖尿病双胍二甲双胍治疗可大大降低患癌症的风险。在我们的动物研究中，二甲双胍可延迟转基因HER-2 / neu小鼠的乳腺腺癌（MAC）发作，但不会延迟雌性SHR小鼠的自发性乳腺肿瘤发作。松果体激素还抑制HER2 / neu转基因小鼠以及雌性SHR小鼠的乳腺癌发展。在这里，我们证明了二甲双胍和褪黑激素的组合可显着抑制小鼠移植肿瘤的生长。在HER2 / neu小鼠中，二甲双胍（0.5 mg / ml的饮用水）可使平均寿命延长8％，MAC潜伏期延长13.2％（p <0.05）。单独用褪黑激素治疗（夜间饮用水中为2 mg / L）或联合使用二甲双胍（白天处理饮用水中为0.5 mg / ml）+褪黑素（夜间为饮用水中的2 mg / L）联合治疗）不影响小鼠的乳房癌变。单独的二甲双胍治疗在移植后第45天将FVB / N雄性小鼠的可移植性HER2乳腺癌抑制了46％（p <0.001）。二甲双胍+褪黑激素的联合治疗显着抑制了埃里希氏肿瘤的生长（降低40％，p <0.001）。这些结果表明二甲双胍可能在乳腺癌的预防和治疗中有用。

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