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首页> 外文期刊>Cell cycle >Uncovering a unique role for DNA methylation in hematopoietic and leukemic stem cells.
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Uncovering a unique role for DNA methylation in hematopoietic and leukemic stem cells.

机译：在造血干细胞和白血病干细胞中发现DNA甲基化的独特作用。

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摘要

Understanding the molecular mechanisms that underlie the fate choices of somatic stem cells is a major goal of today's research as this is essential for the potential exploitation of stem cells in regenerative medicine. Moreover, this knowledge is of great significance when it comes to counteracting the functions of cancer stem cells (CSCs), which are believed to be regulated by mechanisms similar to those in normal stem cells. Increasing evidence points towards a pivotal role of epigenetic mechanisms in orchestrating the highly complex gene networks which guide the options of a stem cell along multiple possible fates. It has been known for quite some time that differential histone tail modifications can control stem cell functions. However, only very recently it has been appreciated that DNA methylation represents another dynamic epigenetic mark that undergoes extensive remodeling during the differentiation of self-renewing stem cells.
机译：了解构成体干细胞命运选择的分子机制是当今研究的主要目标，因为这对于再生医学中干细胞的潜在开发至关重要。此外，这种知识在抵消癌症干细胞（CSC）的功能方面具有重要意义，据信癌症干细胞（CSC）的功能与正常干细胞中的机制类似。越来越多的证据表明，表观遗传机制在编排高度复杂的基因网络中起着关键作用，这些基因网络指导干细胞在多种可能的命运中的选择。一段时间以来，人们已经知道，差异化的组蛋白尾部修饰可以控制干细胞的功能。然而，直到最近才意识到，DNA甲基化代表了另一个动态表观遗传标记，该标记在自我更新干细胞分化过程中经历了广泛的重塑。

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