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A histone methylation code for SV40 minichromosomes.

机译:SV40微型染色体的组蛋白甲基化代码。

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摘要

Chromatin structure and function is dynamically regulated, in part, by the various post-translational modifications on the DNA-associated histone proteins. These histone modifications can occur alone or in combination at specific loci to create a "histone code" that is directly associated with a distinct DNA-templated process such as transcription or replication. Although many studies throughout the last few decades have greatly increased our understanding of histone modification functions in eukaryotes, very little is known about the role of histone modifications within viral genomes.
机译:染色质的结构和功能部分地由与DNA相关的组蛋白的各种翻译后修饰而动态调节。这些组蛋白修饰可以单独发生,也可以在特定位点结合发生,形成“组蛋白密码”,该密码直接与不同的DNA模板化过程(例如转录或复制)相关。尽管过去几十年来的许多研究极大地增进了我们对真核生物中组蛋白修饰功能的了解,但对组蛋白修饰在病毒基因组中的作用了解甚少。

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